TY  -  
T1  - The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity : an [F-18]-DOPA PET study 
SN  -  /  
UR  - http://hdl.handle.net/10138/286193 
T3  -  
A1  - Dahoun, Tarik; Pardinas, Antonio F.; Veronese, Mattia; Bloomfield, Michael A. P.; Jauhar, Sameer; Bonoldi, Ilaria; Froudist-Walsh, Sean; Nosarti, Chiara; Korth, Carsten; Hennah, William; Walters, James; Prata, Diana; Howes, Oliver D. 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Whilst the role of the Disrupted-in-Schizophrenia 1 (DISC1) gene in the aetiology of major mental illnesses is debated, the characterization of its function lends it credibility as a candidate. A key aspect of this functional characterization is the determination of the role of common non-synonymous polymorphisms on normal variation within these functions. The common allele (A) of the DISCI single-nucleotide polymorphism (SNP) rs821616 encodes a serine (ser) at the Ser704Cys polymorphism, and ha... 
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IS  -  
SP  -  
OP  -  
KW  - POSITRON-EMISSION-TOMOGRAPHY; BIPOLAR AFFECTIVE-DISORDER; GENETIC RISK-FACTOR; TYROSINE-HYDROXYLASE; MENTAL-ILLNESS; SCHIZOPHRENIA EVIDENCE; DEPRESSED-PATIENTS; BASAL GANGLIA; PART II; ASSOCIATION; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology; 1184 Genetics, developmental biology, physiology 
N1  -   
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ER  -