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T1  - The polymyxin derivative NAB739 is synergistic with several antibiotics against polymyxin-resistant strains of Escherichia coli, Klebsiella pneumoniae and Acinetobacter baumannii 
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UR  - http://hdl.handle.net/10138/313768 
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A1  - Tyrrell, Jonathan M.; Aboklaish, Ali F.; Walsh, Timothy R.; Vaara, Timo; Vaara, Martti 
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Y1  - 2019 
LA  - eng 
AB  - The antibiotic crisis has reinstated polymyxins, once abandoned because of their toxicity. Now, preclinical studies have revealed better tolerated and more effective derivatives of polymyxins such as NAB739. Simultaneously, polymyxin-resistant (PMR) strains such as the mcr-1 strains have received lots of justified publicity, even though they are still very rare. Here we show that NAB739 sensitizes the PMR strains to rifampin, a classic "anti-Gram-positive" antibiotic excluded by the intact outer... 
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KW  - Polymyxin B; NAB739; Klebsiella pneumoniae; Escherichia coli; Acinetobacter baumannii; mcr-1; Polymyxin resistance; Rifampin; Retapamulin; Meropenem; GRAM-NEGATIVE BACTERIA; 3 POSITIVE CHARGES; SUSCEPTIBILITY TESTING METHODS; MECHANISMS; AGENTS; AGAR; 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology 
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