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T1  - The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis 
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UR  - http://hdl.handle.net/10138/161921 
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A1  - Lahtela, Jenni; Pradhan, Barun; Narhi, Katja; hemmes, Annabrita; Sarkioja, Merja; Kovanen, Panu E.; Brown, Arthur; Verschuren, Emmy W. 
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PB  -  
Y1  - 2015 
LA  - eng 
AB  - Treatment of non-small cell lung cancer (NSCLC) is based on histological analysis and molecular profiling of targetable driver oncogenes. Therapeutic responses are further defined by the landscape of passenger mutations, or loss of tumor suppressor genes. We report here a thorough study to address the physiological role of the putative lung cancer tumor suppressor EPH receptor A3 (EPHA3), a gene that is frequently mutated in human lung adenocarcinomas. Our data shows that homozygous or heterozyg... 
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KW  - EPHA3; EPH receptor A3; GEMM; Adenocarcinoma; Lung morphogenesis; RECEPTOR TYROSINE KINASE; K-RAS; CANCER; ADENOCARCINOMA; EXPRESSION; GROWTH; MICE; DIFFERENTIATION; MECHANISMS; MOUSE; 3122 Cancers; 3121 General medicine, internal medicine and other clinical medicine 
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