TY - T1 - The viral protein corona directs viral pathogenesis and amyloid aggregation SN - / UR - http://hdl.handle.net/10138/302827 T3 - A1 - Ezzat, Kariem; Pernemalm, Maria; Palsson, Sandra; Roberts, Thomas C.; Järver, Peter; Dondalska, Aleksandra; Bestas, Burcu; Sobkowiak, Michal J.; Levänen, Bettina; Sköld, Magnus; Thompson, Elizabeth A.; Saher, Osama; Kari, Otto K.; Lajunen, Tatu; Ekstrom, Eva Sverremark; Nilsson, Caroline; Ishchenko, Yevheniia; Malm, Tarja; Wood, Matthew J. A.; Power, Ultan F.; Masich, Sergej; Linden, Anders; Sandberg, Johan K.; Lehtiö, Janne; Spetz, Anna-Lena; EL Andaloussi, Samir A2 - PB - Y1 - 2019 LA - eng AB - Artificial nanoparticles accumulate a protein corona layer in biological fluids, which significantly influences their bioactivity. As nanosized obligate intracellular parasites, viruses share many biophysical properties with artificial nanoparticles in extracellular environments and here we show that respiratory syncytial virus (RSV) and herpes simplex virus type 1 (HSV-1) accumulate a rich and distinctive protein corona in different biological fluids. Moreover, we show that corona pre-coating d... VO - IS - SP - OP - KW - RESPIRATORY SYNCYTIAL VIRUS; BETA; RECEPTOR; NANOPARTICLES; INFECTION; IMMUNITY; OPPORTUNITIES; FIBRILLATION; FIBRINOGEN; RISK; 3111 Biomedicine N1 - PP - ER -