TY - T1 - Three-Dimensional cryoEM Reconstruction of Native LDL Particles to 16 angstrom Resolution at Physiological Body Temperature SN - / UR - http://hdl.handle.net/10138/165655 T3 - A1 - Kumar, Vibhor; Butcher, Sarah J.; Öörni, Katariina; Engelhardt, Peter; Heikkonen, Jukka; Kaski, Kimmo; Ala-Korpela, Mika; Kovanen, Petri T. A2 - PB - Y1 - 2011 LA - eng AB - Background Low-density lipoprotein (LDL) particles, the major carriers of cholesterol in the human circulation, have a key role in cholesterol physiology and in the development of atherosclerosis. The most prominent structural components in LDL are the core-forming cholesteryl esters (CE) and the particle-encircling single copy of a huge, non-exchangeable protein, the apolipoprotein B-100 (apoB-100). The shape of native LDL particles and the conformation of native apoB-100 on the particles remai... VO - IS - SP - OP - KW - LOW-DENSITY-LIPOPROTEIN; CRYOELECTRON MICROSCOPY; APOLIPOPROTEIN-B; STATISTICAL-ANALYSIS; SERUM-LIPOPROTEINS; TRANSFER PROTEIN; MODEL; LIPOVITELLIN; IMAGES; B-100; 1182 Biochemistry, cell and molecular biology N1 - PP - ER -