TY - T1 - Thrombosis and Inflammation-A Dynamic Interplay and the Role of Glycosaminoglycans and Activated Protein C SN - / UR - http://hdl.handle.net/10138/343690 T3 - A1 - Kohli, Shrey; Shahzad, Khurrum; Jouppila, Annukka; Holthöfer, Harry; Isermann, Berend; Lassila, Riitta A2 - PB - Y1 - 2022 LA - eng AB - Hemostasis, thrombosis, and inflammation are tightly interconnected processes which may give rise to thrombo-inflammation, involved in infectious and non-infectious acute and chronic diseases, including cardiovascular diseases (CVD). Traditionally, due to its hemostatic role, blood coagulation is isolated from the inflammation, and its critical contribution in the progressing CVD is underrated, until the full occlusion of a critical vessel occurs. Underlying vascular injury exposes extracellular... VO - IS - SP - OP - KW - thrombo-inflammation; neutrophil extracellular traps (NETs); activated protein C (aPC); glycosamine glycans; platelet-neutrophil complexes; platelet activation; NEUTROPHIL EXTRACELLULAR TRAPS; VON-WILLEBRAND-FACTOR; P-SELECTIN; MYOCARDIAL-INFARCTION; PLATELET ACTIVATION; NLRP3 INFLAMMASOME; HEPARAN-SULFATE; FACTOR-V; ATHEROSCLEROSIS; ANTICOAGULANT N1 - PP - ER -