TY - T1 - Time is of the essence : Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine SN - / UR - http://hdl.handle.net/10138/330390 T3 - A1 - Kohtala, S.; Alitalo, O.; Rosenholm, M.; Rozov, S.; Rantamäki, T. A2 - PB - Y1 - 2021 LA - eng AB - Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating depression and suicidal ideation. Intense research efforts have been undertaken to expose the precise mechanism underlying the antidepressant action of ketamine; however, the translation of findings into new clinical treatments has been slow. This translational gap is partially explained by a lack of understanding of the function of time and circadian timing in the complex neurobiology around ketamine. Indeed,... VO - IS - SP - OP - KW - Sleep; Circadian; Plasticity; Depression; Rapid-acting antidepressant; Slow-wave sleep; GLYCOGEN-SYNTHASE KINASE-3; RESISTANT MAJOR DEPRESSION; LONG-TERM POTENTIATION; CLOCK GENE-EXPRESSION; BRIGHT LIGHT THERAPY; BLOOD-BRAIN-BARRIER; SLOW-WAVE ACTIVITY; SUPRACHIASMATIC NUCLEUS; NEUROTROPHIC FACTOR; PREFRONTAL CORTEX; 317 Pharmacy; 3112 Neurosciences N1 - PP - ER -