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T1  - Time-differentiated target temperature management after out-of-hospital cardiac arrest : a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial 
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UR  - http://hdl.handle.net/10138/163045 
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A1  - Kirkegaard, Hans; Rasmussen, Bodil S.; de Haas, Inge; Nielsen, Jorgen Feldbaek; Ilkjaer, Susanne; Kaltoft, Anne; Jeppesen, Anni Norregaard; Grejs, Anders; Duez, Christophe Henri Valdemar; Larsen, Alf Inge; Pettila, Ville; Toome, Valdo; Arus, Urmet; Taccone, Fabio Silvio; Storm, Christian; Skrifvars, Markus; Soreide, Eldar 
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Y1  - 2016 
LA  - eng 
AB  - Background: The application of therapeutic hypothermia (TH) for 12 to 24 hours following out-of-hospital cardiac arrest (OHCA) has been associated with decreased mortality and improved neurological function. However, the optimal duration of cooling is not known. We aimed to investigate whether targeted temperature management (TTM) at 33 +/- 1 degrees C for 48 hours compared to 24 hours results in a better long-term neurological outcome. Methods: The TTH48 trial is an investigator-initiated pragm... 
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KW  - Out-of-hospital cardiac arrest; Target temperature management; Mild therapeutic hypothermia; Prolonged target temperature management; INTERNATIONAL LIAISON COMMITTEE; EUROPEAN-RESUSCITATION-COUNCIL; AMERICAN-HEART-ASSOCIATION; GLOBAL CEREBRAL-ISCHEMIA; THERAPEUTIC HYPOTHERMIA; MILD HYPOTHERMIA; COMATOSE SURVIVORS; STROKE-FOUNDATION; TASK-FORCE; STATEMENT; 3126 Surgery, anesthesiology, intensive care, radiology 
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