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T1  - Traditional and new emerging methods to study drug permeability and drug-cell interactions in early phases of drug discovery (Literature review) : Monitoring drug-cell interactions with surface plasmon resonance technique (Experimental study) 
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UR  - URN:NBN:fi-fe201801151218; http://hdl.handle.net/10138/38940 
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A1  - Hallila, Susanna 
A2  -  
PB  - Helsingfors universitet 
Y1  - 2013 
LA  - eng 
AB  - There is a strong need for new in vitro methods in early drug development that predict in vivo conditions more reliably. One of the prerequisites for successful drug therapy is sufficient permeability. A drug needs to be transported through a cell membrane before it can have a pharmacological effect. Therefore, the drug-cell interactions are studied in the early stage of the drug development process. The literature review of this work covers the traditional in vitro and in silico methods of pred... 
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KW  - surface plasmon resonance; intestinal absorption; MDCKII cells; propranolol; D-mannitol; Biofarmaci; Biopharmacy; Biofarmasia 
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ER  -