TY - T1 - Transcriptome and regulatory maps of decidua-derived stromal cells inform gene discovery in preterm birth SN - / UR - http://hdl.handle.net/10138/324971 T3 - A1 - Sakabe, Noboru J.; Aneas, Ivy; Knoblauch, Nicholas; Sobreira, Debora R.; Clark, Nicole; Paz, Cristina; Horth, Cynthia; Ziffra, Ryan; Kaur, Harjot; Liu, Xiao; Anderson, Rebecca; Morrison, Jean; Cheung, Virginia C.; Grotegut, Chad; Reddy, Timothy E.; Jacobsson, Bo; Hallman, Mikko; Teramo, Kari; Murtha, Amy; Kessler, John; Grobman, William; Zhang, Ge; Muglia, Louis J.; Rana, Sarosh; Lynch, Vincent J.; Crawford, Gregory E.; Ober, Carole; He, Xin; Nobrega, Marcelo A. A2 - PB - Y1 - 2020 LA - eng AB - While a genetic component of preterm birth (PTB) has long been recognized and recently mapped by genome-wide association studies (GWASs), the molecular determinants underlying PTB remain elusive. This stems in part from an incomplete availability of functional genomic annotations in human cell types relevant to pregnancy and PTB. We generated transcriptome (RNA-seq), epigenome (ChlP-seq of H3K27ac, H3K4mel, and H3K4me3 histone modifications), open chromatin (ATAC-seq), and chromatin interaction ... VO - IS - SP - OP - KW - GENOME-WIDE ASSOCIATION; PROGESTERONE-RECEPTOR; DECIDUALIZATION; ENDOMETRIUM; EXPRESSION; PRINCIPLES; REVEALS; BINDING; COHORT; FOXO1; 3123 Gynaecology and paediatrics N1 - PP - ER -