TY  -  
T1  - Transdifferentiation of pancreatic cells by loss of contact-mediated signaling 
SN  -  /  
UR  - http://hdl.handle.net/10138/164361 
T3  -  
A1  - de Back, Walter; Zimm, Roland; Brusch, Lutz 
A2  -  
PB  -  
Y1  - 2013 
LA  - eng 
AB  - Background: Replacement of dysfunctional beta-cells in the islets of Langerhans by transdifferentiation of pancreatic acinar cells has been proposed as a regenerative therapy for diabetes. Adult acinar cells spontaneously revert to a multipotent state upon tissue dissociation in vitro and can be stimulated to redifferentiate into beta-cells. Despite accumulating evidence that contact-mediated signals are involved, the mechanisms regulating acinar-to-islet cell transdifferentiation remain poorly ... 
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IS  -  
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KW  - Lineage conversion; Intercellular communication; Reprogramming; Pancreas; Acinar cells; Islet cells; Mathematical model; Multicellular systems biology; E-CADHERIN; IN-VITRO; STEM-CELLS; REGENERATIVE MEDICINE; ACINAR-CELLS; BETA-CELLS; DIFFERENTIATION; EXPRESSION; NOTCH; PTF1A; 114 Physical sciences 
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ER  -