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T1  - Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity 
SN  -  /  
UR  - http://hdl.handle.net/10138/240783 
T3  -  
A1  - Anthoni, M.; Fyhrquist-Vanni, N.; Wolff, H.; Alenius, H.; Lauerma, A. 
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PB  -  
Y1  - 2008 
LA  - eng 
AB  - Background Transforming growth factor (TGF)-beta is an important modulator of immune functions and cellular responses, such as differentiation, proliferation, migration and apoptosis. The Smad proteins, which are intracellular TGF-beta signal transducers, mediate most actions of TGF-beta. Objectives This study examines the role of Smad3 in a murine model of contact hypersensitivity (CHS). Methods The CHS response to oxazolone was studied in Smad3-deficient mice. The ear swelling response was mea... 
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KW  - chemokine; contact hypersensitivity; cytokine murine model; Smad3; transforming growth factor-beta; GROWTH-FACTOR-BETA; IL-17-PRODUCING T-CELLS; TGF-BETA; ATOPIC-DERMATITIS; TARGETED DISRUPTION; SKIN INFLAMMATION; FOXP3 EXPRESSION; IGE RESPONSE; SMAD3; MACROPHAGE 
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ER  -