TY - T1 - Transforming growth factor-beta/Smad3 signalling regulates inflammatory responses in a murine model of contact hypersensitivity SN - / UR - http://hdl.handle.net/10138/240783 T3 - A1 - Anthoni, M.; Fyhrquist-Vanni, N.; Wolff, H.; Alenius, H.; Lauerma, A. A2 - PB - Y1 - 2008 LA - eng AB - Background Transforming growth factor (TGF)-beta is an important modulator of immune functions and cellular responses, such as differentiation, proliferation, migration and apoptosis. The Smad proteins, which are intracellular TGF-beta signal transducers, mediate most actions of TGF-beta. Objectives This study examines the role of Smad3 in a murine model of contact hypersensitivity (CHS). Methods The CHS response to oxazolone was studied in Smad3-deficient mice. The ear swelling response was mea... VO - IS - SP - OP - KW - chemokine; contact hypersensitivity; cytokine murine model; Smad3; transforming growth factor-beta; GROWTH-FACTOR-BETA; IL-17-PRODUCING T-CELLS; TGF-BETA; ATOPIC-DERMATITIS; TARGETED DISRUPTION; SKIN INFLAMMATION; FOXP3 EXPRESSION; IGE RESPONSE; SMAD3; MACROPHAGE N1 - PP - ER -