TY  -  
T1  - Transient modification of lin28b expression - Permanent effects on zebrafish growth 
SN  -  /  
UR  - http://hdl.handle.net/10138/274089 
T3  -  
A1  - Leinonen, Jaakko T.; Chen, Yu-Chia; Tukiainen, Taru; Panula, Pertti; Widen, Elisabeth 
A2  -  
PB  -  
Y1  - 2019 
LA  - eng 
AB  - Recent genome-wide association studies and mouse models have identified LIN28B as a gene affecting several pubertal timing-related traits and vertebrate growth. However, the exact biological mechanisms underlying the associations remain unknown. We have explored the mechanisms linking LIN28B with growth regulation by combining human gene expression data with functional models. Specifically, we show that 1) pubertal timing-associated genetic variation correlates with LIN28B expression in the pitu... 
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KW  - Lin28b; Zebrafish; Development; Hypothalamus; Kiss2; HYPOGONADOTROPIC HYPOGONADISM; EMBRYONIC-DEVELOPMENT; LET-7 MICRORNA; LOCI; HEIGHT; AGE; PHENOTYPES; PROTEINS; NEURONS; SYSTEM; 3111 Biomedicine 
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