TY  -  
T1  - Transmembrane Domain Single-Nucleotide Polymorphisms Impair Expression and Transport Activity of ABC Transporter ABCG2 
SN  -  /  
UR  - http://hdl.handle.net/10138/215611 
T3  -  
A1  - Sjöstedt, Noora; van den Heuvel, Jeroen J. M. W.; Koenderink, Jan B.; Kidron, Heidi 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - To study the function and expression of nine naturally occurring single-nucleotide polymorphisms (G406R, F431L, S441N, P480L, F489L, M515R, L525R, A528T and T542A) that are predicted to reside in the transmembrane regions of the ABC transporter ABCG2. The transport activity of the variants was tested in inside-out membrane vesicles from Sf9 insect and human derived HEK293 cells overexpressing ABCG2. Lucifer Yellow and estrone sulfate were used as probe substrates of activity. The expression leve... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - BCRP; genetic variant; interindividual variability; pharmacogenetics; SNP; CANCER-RESISTANCE-PROTEIN; BCRP GENE POLYMORPHISMS; IN-VITRO; LOCALIZATION; MUTATIONS; IDENTIFICATION; INHIBITION; BCRP/ABCG2; VARIANTS; CELLS; 116 Chemical sciences; 317 Pharmacy 
N1  -   
PP  -  
ER  -