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T1  - Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes 
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UR  - http://hdl.handle.net/10138/327783 
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A1  - Byts, Nadiya; Sharma, Subodh; Laurila, Jenny; Paudel, Prodeep; Miinalainen, Ilkka; Ronkainen, Veli-Pekka; Hinttala, Reetta; Törnquist, Kid; Koivunen, Peppi; Myllyharju, Johanna 
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Y1  - 2021 
LA  - eng 
AB  - Prolyl 4-hydroxylases (P4Hs) have vital roles in regulating collagen synthesis and hypoxia response. A trans membrane P4H (P4H-TM) is a recently identified member of the family. Biallelic loss of function P4H-TM mutations cause a severe autosomal recessive intellectual disability syndrome in humans, but functions of P4H-TM are essentially unknown at cellular level. Our microarray data on P4h-tm(-/-) mouse cortexes where P4H-TM is abundantly expressed indicated expression changes in genes involve... 
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KW  - calcium signaling; hypoxia-inducible factor; prolyl 4-hydroxylase; vesicular exocytosis; ENDOPLASMIC-RETICULUM STRESS; MITOCHONDRIAL CA2+ UPTAKE; INTRACELLULAR CALCIUM; CA2+-DEPENDENT EXOCYTOSIS; SUPEROXIDE-DISMUTASE; PREFRONTAL CORTEX; PROTEIN-SYNTHESIS; OXIDATIVE STRESS; GENE-EXPRESSION; DOWN-REGULATION; 3112 Neurosciences; 3124 Neurology and psychiatry 
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