TY - T1 - Transportable system enabling multiple irradiation studies under simultaneous hypoxia in vitro SN - / UR - http://hdl.handle.net/10138/270210 T3 - A1 - Metsälä, Olli; Kreutzer, Joose; Högel, Heidi; Miikkulainen, Petra; Kallio, Pasi; Jaakkola, Panu M. A2 - PB - Y1 - 2018 LA - eng AB - BackgroundCells in solid tumours are variably hypoxic and hence resistant to radiotherapy - the essential role of oxygen in the efficiency of irradiation has been acknowledged for decades. However, the currently available methods for performing hypoxic experiments in vitro have several limitations, such as a limited amount of parallel experiments, incapability of keeping stable growth conditions and dependence on CO2 incubator or a hypoxia workstation. The purpose of this study was to evaluate t... VO - IS - SP - OP - KW - Hypoxia; Cancer; Radiotherapy; Radiation; In vitro; Minihypoxy; CANCER-CELLS; OXYGEN CONCENTRATION; TUMOR RADIORESPONSE; CULTURE; RADIOSENSITIVITY; REOXYGENATION; CYCLE; ENHANCEMENT; HIF-1-ALPHA; EXPRESSION; 3122 Cancers; 3126 Surgery, anesthesiology, intensive care, radiology N1 - PP - ER -