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T1  - Two high-risk susceptibility loci at 6p25.3 and 14q32.13 for Waldenström macroglobulinemia 
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UR  - http://hdl.handle.net/10138/299705 
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A1  - Waldenström macroglobulinemia Group 
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Y1  - 2018 
LA  - eng 
AB  - Waldenström macroglobulinemia (WM)/lymphoplasmacytic lymphoma (LPL) is a rare, chronic B-cell lymphoma with high heritability. We conduct a two-stage genome-wide association study of WM/LPL in 530 unrelated cases and 4362 controls of European ancestry and identify two high-risk loci associated with WM/LPL at 6p25.3 (rs116446171, near EXOC2 and IRF4; OR = 21.14, 95% CI: 14.40–31.03, P = 1.36 × 10 −54 ) and 14q32.13 (rs117410836, near TCL1; OR = 4.90, 95% CI: 3.45–6.96, P = 8.75 × 10 −19 ). Both r... 
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KW  - enhanced green fluorescent protein; green fluorescent protein; microRNA; cell proliferation; chromosome 14; chromosome 6; family; genetic predisposition; genetics; genotyping technique; HEK293 cell line; human; inheritance; metabolism; molecular genetics; nucleotide sequence; reporter gene; reproducibility; risk factor; single nucleotide polymorphism; Waldenstroem macroglobulinemia; Base Sequence; Cell Proliferation; Chromosomes, Human, Pair 14; Chromosomes, Human, Pair 6; Family; Genes, Reporter; Genetic Predisposition to Disease; Genotyping Techniques; Green Fluorescent Proteins; HEK293 Cells; Humans; Inheritance Patterns; MicroRNAs; Molecular Sequence Annotation; Polymorphism, Single Nucleotide; Reproducibility of Results; Risk Factors; Waldenstrom Macroglobulinemia; 1184 Genetics, developmental biology, physiology 
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