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T1  - Two-fold elevation of endogenous GDNF levels in mice improves motor coordination without causing side-effects 
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UR  - http://hdl.handle.net/10138/238814 
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A1  - Mätlik, Kärt; Võikar, Vootele; Vilenius, Carolina; Kulesskaya, Natalia; Andressoo, Jaan-Olle 
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Y1  - 2018 
LA  - eng 
AB  - Glial cell line-derived neurotrophic factor (GDNF) promotes the survival of dopaminergic neurons in vitro and in vivo. For this reason, GDNF is currently in clinical trials for the treatment of Parkinson’s disease (PD). However, how endogenous GDNF influences dopamine system function and animal behavior is not fully understood. We recently generated GDNF hypermorphic mice that express increased levels of endogenous GDNF from the native locus, resulting in augmented function of the nigrostriatal ... 
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KW  - 3112 Neurosciences; 1182 Biochemistry, cell and molecular biology; NEUROTROPHIC-FACTOR GDNF; NIGROSTRIATAL DOPAMINE SYSTEM; AGED FISCHER-344 RATS; PARKINSONS-DISEASE; TYROSINE-HYDROXYLASE; IN-VIVO; MESOLIMBIC DOPAMINE; PREPULSE INHIBITION; AGGRESSIVE-BEHAVIOR; LOCOMOTOR-ACTIVITY 
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