TY - T1 - Uncovering the Tumor Antigen Landscape : What to Know about the Discovery Process SN - / UR - http://hdl.handle.net/10138/318431 T3 - A1 - Feola, Sara; Chiaro, Jacopo; Martins, Beatriz; Cerullo, Vincenzo A2 - PB - Y1 - 2020 LA - eng AB - According to the latest available data, cancer is the second leading cause of death, highlighting the need for novel cancer therapeutic approaches. In this context, immunotherapy is emerging as a reliable first-line treatment for many cancers, particularly metastatic melanoma. Indeed, cancer immunotherapy has attracted great interest following the recent clinical approval of antibodies targeting immune checkpoint molecules, such as PD-1, PD-L1, and CTLA-4, that release the brakes of the immune s... VO - IS - SP - OP - KW - tumor antigens; immunopeptidome; cancer immunotherapy; epitope prediction; MHC CLASS-I; CYTOLYTIC T-LYMPHOCYTES; MASS-SPECTROMETRIC IDENTIFICATION; DISTINCT PROTEOLYTIC PROCESSES; TAP TRANSPORT EFFICIENCY; CELL EPITOPES; PREDICTING IMMUNOGENICITY; BINDING PEPTIDES; IMMUNE-RESPONSES; HIGH-THROUGHPUT; 3111 Biomedicine; 3122 Cancers; 317 Pharmacy N1 - PP - ER -