TY  -  
T1  - Uncovering the Tumor Antigen Landscape : What to Know about the Discovery Process 
SN  -  /  
UR  - http://hdl.handle.net/10138/318431 
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A1  - Feola, Sara; Chiaro, Jacopo; Martins, Beatriz; Cerullo, Vincenzo 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - According to the latest available data, cancer is the second leading cause of death, highlighting the need for novel cancer therapeutic approaches. In this context, immunotherapy is emerging as a reliable first-line treatment for many cancers, particularly metastatic melanoma. Indeed, cancer immunotherapy has attracted great interest following the recent clinical approval of antibodies targeting immune checkpoint molecules, such as PD-1, PD-L1, and CTLA-4, that release the brakes of the immune s... 
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KW  - tumor antigens; immunopeptidome; cancer immunotherapy; epitope prediction; MHC CLASS-I; CYTOLYTIC T-LYMPHOCYTES; MASS-SPECTROMETRIC IDENTIFICATION; DISTINCT PROTEOLYTIC PROCESSES; TAP TRANSPORT EFFICIENCY; CELL EPITOPES; PREDICTING IMMUNOGENICITY; BINDING PEPTIDES; IMMUNE-RESPONSES; HIGH-THROUGHPUT; 3111 Biomedicine; 3122 Cancers; 317 Pharmacy 
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ER  -