TY - T1 - Underlying Mechanisms of Prolyl Oligopeptidase Inhibition, Deletion, and Restoration on the α-Synuclein Aggregation Process SN - / UR - URN:ISBN:978-951-51-4818-6; http://hdl.handle.net/10138/287678 T3 - A1 - Svarcbahs, Reinis A2 - PB - Helsingin yliopisto Y1 - 2019 LA - en AB - Neurodegenerative disorders are characterized by accumulation of toxic protein species that are followed by a gradual loss of neurons in certain brain regions and person’s loss of movement and dementia. The cause of the protein accumulation is not fully understood but is partially influenced by the disturbances in the protein degradation pathways, post-translational protein modifications that facilitate either gain-of-toxicity or loss-of-function of these proteins. In Parkinson’s disease, the be... VO - IS - SP - OP - KW - pharmacology N1 - PP - ER -