TY  -  
T1  - Unraveling of Central Nervous System Disease Mechanisms Using CRISPR Genome Manipulation 
SN  -  /  
UR  - http://hdl.handle.net/10138/299403 
T3  -  
A1  - Vesikansa, Aino 
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PB  -  
Y1  - 2018 
LA  - eng 
AB  - The complex structure and highly variable gene expression profile of the brain makes it among the most challenging fields to study in both basic and translational biological research. Most of the brain diseases are multifactorial and despite the rapidly increasing genomic data, molecular pathways and causal links between genes and central nervous system (CNS) diseases are largely unknown. The advent of an easy and flexible CRISPR-Cas genome editing technology has rapidly revolutionized the field... 
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KW  - Central nervous system; CRISPR-Cas; CRISPR; brain; CNS disease; genome editing; PLURIPOTENT STEM-CELLS; STAPHYLOCOCCUS-AUREUS CAS9; RNA-GUIDED ENDONUCLEASE; IN-VIVO; ANIMAL-MODELS; HOMOLOGOUS RECOMBINATION; HUNTINGTONS-DISEASE; DNA-REPAIR; NEURODEGENERATIVE DISEASES; GERMLINE TRANSMISSION; 3124 Neurology and psychiatry 
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ER  -