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T1  - Updates in the field of hereditary nonpolyposis colorectal cancer : Expert Review of Gastroenterology & Hepatology 
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UR  - http://hdl.handle.net/10138/318745 
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A1  - Peltomäki, Paivi; Olkinuora, Alisa; Nieminen, Taina T. 
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Y1  - 2020 
LA  - eng 
AB  - ABSTRACT Introduction Up to one third of colorectal cancers show familial clustering and 5% are hereditary single-gene disorders. Hereditary non-polyposis colorectal cancer comprises DNA mismatch repair-deficient and -proficient subsets, represented by Lynch syndrome (LS) and familial colorectal cancer type X (FCCTX), respectively. Accurate knowledge of molecular etiology and genotype-phenotype correlations are critical for tailored cancer prevention and treatment. Areas covered The authors high... 
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KW  - 3121 General medicine, internal medicine and other clinical medicine; 3122 Cancers; Hereditary non-polyposis colorectal cancer; lynch syndrome; familial colorectal cancer type X; DNA mismatch repair; genomic instability; germline mutation; constitutional epimutation; MISMATCH REPAIR-DEFICIENCY; LYNCH-SYNDROME; GERMLINE MUTATIONS; RIBOSOMAL-PROTEIN; DNA-DAMAGE; GENOMIC REARRANGEMENTS; PROMOTER METHYLATION; ENDOMETRIAL CANCERS; POLYPOSIS SYNDROME; SOMATIC MUTATIONS 
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