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T1  - Use of HOMA-IR to diagnose non-alcoholic fatty liver disease : a population-based and inter-laboratory study 
SN  -  /  
UR  - http://hdl.handle.net/10138/243747 
T3  -  
A1  - Isokuortti, Elina; Zhou, You; Peltonen, Markku; Bugianesi, Elisabetta; Clement, Karine; Bonnefont-Rousselot, Dominique; Lacorte, Jean-Marc; Gastaldelli, Amalia; Schuppan, Detlef; Schattenberg, Joern M.; Hakkarainen, Antti; Lundbom, Nina; Jousilahti, Pekka; Mannisto, Satu; Keinanen-Kiukaanniemi, Sirkka; Saltevo, Juha; Anstee, Quentin M.; Yki-Jarvinen, Hannele 
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PB  -  
Y1  - 2017 
LA  - eng 
AB  - Aims/hypothesis Recent European guidelines for nonalcoholic fatty liver disease (NAFLD) call for reference values for HOMA-IR. In this study, we aimed to determine: (1) the upper limit of normal HOMA-IR in two population-based cohorts; (2) the HOMA-IR corresponding to NAFLD; (3) the effect of sex and PNPLA3 genotype at rs738409 on HOMA-IR; and (4) inter-laboratory variations in HOMA-IR. Methods We identified healthy individuals in two population-based cohorts (FINRISK 2007 [n = 5024] and the Pro... 
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KW  - Insulin; Liver fat; NAFLD; PNPLA3; Reference values; HOMEOSTASIS MODEL ASSESSMENT; TYPE-2 DIABETES-MELLITUS; INSULIN-RESISTANCE; METABOLIC SYNDROME; GLUCOSE-TOLERANCE; HEPATIC STEATOSIS; THRESHOLD VALUE; PIMA-INDIANS; GENE VARIANT; 3121 General medicine, internal medicine and other clinical medicine 
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