TY - T1 - Vacuolar Storage Disease in Lagotto Romagnolo Dogs : Pathology, autophagy and extracellular vesicles SN - / UR - URN:ISBN:978-951-51-6679-1; http://hdl.handle.net/10138/320217 T3 - A1 - Syrjä, Pernilla A2 - PB - Helsingin yliopisto Y1 - 2020 LA - en AB - This thesis aimed at describing the pathology of a novel progressive neurologic disease in dogs of the Lagotto Romagnolo (LR) breed, at testing the hypothesis of altered autophagy in affected dogs, derived from genetic investigations, and at testing the hypothesis of a lysosomal storage disease affecting the dogs, derived from the histopathologic changes. Autophagy is a degradative cellular process, responsible for the turnover of damaged organelles and clearance of protein aggregates, that ... VO - IS - SP - OP - KW - veterinary Pathology N1 - PP - ER -