TY  -  
T1  - Variation near MTNR1A associates with early development and interacts with seasons 
SN  -  /  
UR  - http://hdl.handle.net/10138/338120 
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A1  - Sulkava, Sonja M; Taka, Antti-Mathias; Kantojärvi, Katri; Pölkki, Pirjo; Morales-Munoz, Isabel; Milani, Lili; Porkka-Heiskanen, Tarja; Saarenpää-Heikkilä, Outi; Kylliäinen, Anneli; Paavonen, E. Juulia; Paunio, Tiina 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Melatonin is a circadian regulatory hormone with neuroprotective properties. We have previously demonstrated the association of the genetic variant rs12506228 near the melatonin receptor 1A gene (MTNR1A) with intolerance to shift‐work. Furthermore, this variant has been connected to Alzheimer's disease. Because of the previously suggested role of melatonin signalling in foetal neurocognitive and sleep development, we studied here the association of rs12506228 with early development. The study sa... 
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KW  - 3123 Gynaecology and paediatrics; sleep; infants; MELATONIN; cognitive development; genetics; infants; MTNR1A; seasonal variation; sleep; INFANT SLEEP PROBLEMS; SERUM MELATONIN; 1ST YEAR; BRAIN; CHILDREN; GROWTH; RISK; POPULATION; COGNITION; PATTERNS 
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ER  -