TY  -  
T1  - Vimentin intermediate filaments control actin stress fiber assembly through GEF-H1 and RhoA 
SN  -  /  
UR  - http://hdl.handle.net/10138/183465 
T3  -  
A1  - Jiu, Yaming; Peränen, Johan; Schaible, Niccole; Cheng, Fang; Eriksson, John E.; Krishnan, Ramaswamy; Lappalainen, Pekka 
A2  -  
PB  -  
Y1  - 2017 
LA  - eng 
AB  - The actin and intermediate filament cytoskeletons contribute to numerous cellular processes, including morphogenesis, cytokinesis and migration. These two cytoskeletal systems associate with each other, but the underlying mechanisms of this interaction are incompletely understood. Here, we show that inactivation of vimentin leads to increased actin stress fiber assembly and contractility, and consequent elevation of myosin light chain phosphorylation and stabilization of tropomyosin-4.2 (see Gee... 
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KW  - Vimentin; Intermediate filament; Actin; Stress fiber; RhoA; GEF-H1; NUCLEOTIDE EXCHANGE FACTOR; IN-VIVO; MECHANICAL FORCE; PROSTATE-CANCER; RHOGEF GEF-H1; CELLS; ADHESION; KINASE; CYTOSKELETON; ACTIVATION; 1182 Biochemistry, cell and molecular biology 
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ER  -