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T1  - Western diet enhances intestinal tumorigenesis in Min/ plus mice, associating with mucosal metabolic and inflammatory stress and loss of Apc heterozygosity 
SN  -  /  
UR  - http://hdl.handle.net/10138/309229 
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A1  - Niku, Mikael; Pajari, Anne-Maria; Sarantaus, Laura; Päivärinta, Essi; Storvik, Markus; Heiman-Lindh, Anu; Suokas, Santeri; Nyström, Minna; Mutanen, Marja 
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Y1  - 2017 
LA  - eng 
AB  - Western-type diet (WD) is a risk factor for colorectal cancer, but the underlying mechanisms are poorly understood. We investigated the interaction of WD and heterozygous mutation in the Apc gene on adenoma formation and metabolic and immunological changes in the histologically normal intestinal mucosa of Apc(Min/+) (Min/ +) mice. The diet used was high in saturated fat and low in calcium, vitamin D, fiber and folate. The number of adenomas was twofold higher in the WD mice compared to controls,... 
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KW  - High-risk Western-type diet; Intestinal cancer; Energy metabolism; Loss of heterozygosity; PDK4; ERK; Apc(min/+) mice; HIGH-FAT DIET; COLON-CANCER; APC(MIN/+) MICE; BETA-CATENIN; CELL-PROLIFERATION; INSULIN-RESISTANCE; TUMOR-FORMATION; DNA-DAMAGE; EXPRESSION; INHIBITOR; 1182 Biochemistry, cell and molecular biology 
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