TY  -  
T1  - Zebrafish Heart Failure Models 
SN  -  /  
UR  - http://hdl.handle.net/10138/332424 
T3  -  
A1  - Narumanchi, Suneeta; Wang, Hong; Perttunen, Sanni; Tikkanen, Ilkka; Lakkisto, Päivi; Paavola, Jere 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Heart failure causes significant morbidity and mortality worldwide. The understanding of heart failure pathomechanisms and options for treatment remain incomplete. Zebrafish has proven useful for modeling human heart diseases due to similarity of zebrafish and mammalian hearts, fast easily tractable development, and readily available genetic methods. Embryonic cardiac development is rapid and cardiac function is easy to observe and quantify. Reverse genetics, by using morpholinos and CRISPR-Cas9... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - 3111 Biomedicine; 1182 Biochemistry, cell and molecular biology; zebrafish; heart failure; cardiac remodeling; cardiac hypertrophy; cardiomyopathy; TARGETED GENE DISRUPTION; CARDIAC NEURAL CREST; HYPERTROPHIC CARDIOMYOPATHY; ADULT ZEBRAFISH; VENTRICULAR-FUNCTION; TROPONIN-T; PROTEIN; MUTATIONS; CONTRIBUTES; EXPRESSION 
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ER  -