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T1  - miR-34a is upregulated inAIP-mutated somatotropinomas and promotes octreotide resistance 
SN  -  /  
UR  - http://hdl.handle.net/10138/320793 
T3  -  
A1  - Bogner, Eva-Maria; Daly, Adrian F.; Gulde, Sebastian; Karhu, Auli; Irmler, Martin; Beckers, Johannes; Mohr, Hermine; Beckers, Albert; Pellegata, Natalia S. 
A2  -  
PB  -  
Y1  - 2020 
LA  - eng 
AB  - Pituitary adenomas (PAs) are intracranial tumors associated with significant morbidity due to hormonal dysregulation, mass effects and have a heavy treatment burden. Growth hormone (GH)-secreting PAs (somatotropinomas) cause acromegaly-gigantism. Genetic forms of somatotropinomas due to germlineAIPmutations (AIPmut+) have an early onset and are aggressive and resistant to treatment with somatostatin analogs (SSAs), including octreotide. The molecular underpinnings of these clinical features rema... 
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KW  - aryl hydrocarbon receptor-interacting protein; G protein subunit alpha i2; miR-34a; octreotide resistance; pituitary adenoma; PITUITARY-ADENOMA PREDISPOSITION; HYDROCARBON RECEPTOR AHR; INTERACTING PROTEIN; GENE-EXPRESSION; CELL-PROLIFERATION; SIGNALING PATHWAY; DOWN-REGULATION; GROWTH-HORMONE; AIP MUTATIONS; CAMP; 3122 Cancers; 3111 Biomedicine 
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ER  -