TY  -  
T1  - rs10732516 polymorphism at the IGF2/H19 locus associates with genotype-specific effects on placental DNA methylation and birth weight of newborns conceived by assisted reproductive technology 
SN  -  /  
UR  - http://hdl.handle.net/10138/237075 
T3  -  
A1  - Marjonen, Heidi Maria; Auvinen, Pauliina; Kahila, Hanna; Tšuiko, Olga; Kõks, Sulev; Tiirats, Airi; Viltrop, Triin; Tuuri, Timo; Söderström-Anttila, Viveca; Suikkari, Anne-Maria; Salumets, Andres; Tiitinen, Aila; Kaminen-Ahola, Nina 
A2  -  
PB  -  
Y1  - 2018 
LA  - eng 
AB  - Background: Assisted reproductive technology (ART) has been associated with low birth weight of fresh embryo transfer (FRESH) derived and increased birth weight of frozen embryo transfer (FET)-derived newborns. Owing to that, we focused on imprinted insulin-like growth factor 2 (1GF2)/H19 locus known to be important for normal growth. This locus is regulated by H19 imprinting control region (ICR) with seven binding sites for the methylation-sensitive zinc finger regulatory protein (CTCF). A poly... 
VO  -  
IS  -  
SP  -  
OP  -  
KW  - Assisted reproductive technology; IVF; Fresh embryo transfer; Frozen embryo transfer; Imprinting; IGF2/H19; rs10732516; DNA methylation; Placenta; Birth weight; BECKWITH-WIEDEMANN-SYNDROME; IN-VITRO FERTILIZATION; PERINATAL OUTCOMES; EMBRYO-TRANSFER; SINGLETON PREGNANCIES; CHILDREN BORN; METAANALYSIS; IVF/ICSI; FROZEN; COHORT; 3123 Gynaecology and paediatrics 
N1  -   
PP  -  
ER  -