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T1  - rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD : A meta-analysis 
SN  -  /  
UR  - http://hdl.handle.net/10138/324912 
T3  -  
A1  - EU-PNAFLD Investigators; GOLD Consortium; Teo, Kevin; Abeysekera, Kushala W. M.; Luukkonen, Panu K.; Yki-Järvinen, Hannele 
A2  -  
PB  -  
Y1  - 2021 
LA  - eng 
AB  - Background & Aims: A common genetic variant near MBOAT7 (rs641738C>T) has been previously associated with hepatic fat and advanced histology in NAFLD; however, these findings have not been consistently replicated in the literature. We aimed to establish whether rs641738C>T is a risk factor across the spectrum of NAFLD and to characterise its role in the regulation of related metabolic phenotypes through a meta-analysis. Methods: We performed a meta-analysis of studies with data on the associatio... 
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KW  - MBOAT7; Fibrosis; NAFLD; Triglyceride; Diabetes; ALSPAC; GENOME-WIDE ASSOCIATION; RISK LOCI; VARIANT; DISEASE; SEVERITY; PNPLA3; TM6SF2; ACYLTRANSFERASE; EXPRESSION; INSIGHTS; 3121 General medicine, internal medicine and other clinical medicine 
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ER  -