Antifungal Compounds from Cyanobacteria

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Shishido , T K , Humisto , A , Jokela , J , Liu , L , Wahlsten , M , Tamrakar , A , Fewer , D P , Permi , P , Andreote , A P D , Fiore , M F & Sivonen , K 2015 , ' Antifungal Compounds from Cyanobacteria ' , Marine Drugs , vol. 13 , no. 4 , pp. 2124-2140 . https://doi.org/10.3390/md13042124

Title: Antifungal Compounds from Cyanobacteria
Author: Shishido, Tania K.; Humisto, Anu; Jokela, Jouni; Liu, Liwei; Wahlsten, Matti; Tamrakar, Anisha; Fewer, David P.; Permi, Perttu; Andreote, Ana P. D.; Fiore, Marli F.; Sivonen, Kaarina
Other contributor: University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Univ Helsinki, University of Helsinki, Dept Food & Environm Sci, Viikki Bioctr 1
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Department of Food and Nutrition
University of Helsinki, Institute of Biotechnology
University of Helsinki, Department of Food and Nutrition




Date: 2015
Language: eng
Number of pages: 17
Belongs to series: Marine Drugs
ISSN: 1660-3397
DOI: https://doi.org/10.3390/md13042124
URI: http://hdl.handle.net/10138/159298
Abstract: Cyanobacteria are photosynthetic prokaryotes found in a range of environments. They are infamous for the production of toxins, as well as bioactive compounds, which exhibit anticancer, antimicrobial and protease inhibition activities. Cyanobacteria produce a broad range of antifungals belonging to structural classes, such as peptides, polyketides and alkaloids. Here, we tested cyanobacteria from a wide variety of environments for antifungal activity. The potent antifungal macrolide scytophycin was detected in Anabaena sp. HAN21/1, Anabaena cf. cylindrica PH133, Nostoc sp. HAN11/1 and Scytonema sp. HAN3/2. To our knowledge, this is the first description of Anabaena strains that produce scytophycins. We detected antifungal glycolipopeptide hassallidin production in Anabaena spp. BIR JV1 and HAN7/1 and in Nostoc spp. 6sf Calc and CENA 219. These strains were isolated from brackish and freshwater samples collected in Brazil, the Czech Republic and Finland. In addition, three cyanobacterial strains, Fischerella sp. CENA 298, Scytonema hofmanni PCC 7110 and Nostoc sp. N107.3, produced unidentified antifungal compounds that warrant further characterization. Interestingly, all of the strains shown to produce antifungal compounds in this study belong to Nostocales or Stigonematales cyanobacterial orders.
Subject: BLUE-GREEN ALGAE
SCYTOPHYCINS
SCYTONEMA
ANABAENA
LIPOPEPTIDE
RESISTANCE
GROWTH
1172 Environmental sciences
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