Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32330 subjects from the International Cannabis Consortium

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Stringer , S , Minica , C C , Verweij , K J H , Mbarek , H , Bernard , M , Derringer , J , van Eijk , K R , Isen , J D , Loukola , A , Maciejewski , D F , Mihailov , E , van der Most , P J , Sanchez-Mora , C , Roos , L , Sherva , R , Walters , R , Ware , J J , Abdellaoui , A , Bigdeli , T B , Branje , S J T , Brown , S A , Bruinenberg , M , Casas , M , Esko , T , Garcia-Martinez , I , Gordon , S D , Harris , J M , Hartman , C A , Henders , A K , Heath , A C , Hickie , I B , Hickman , M , Hopfer , C J , Hottenga , J J , Huizink , A C , Irons , D E , Kahn , R S , Korhonen , T , Kranzler , H R , Krauter , K , van Lier , P A C , Lubke , G H , Madden , P A F , Magi , R , McGue , M K , Medland , S E , Meeus , W H J , Miller , M B , Montgomery , G W , Nivard , M G , Nolte , I M , Oldehinkel , A J , Pausova , Z , Qaiser , B , Quaye , L , Ramos-Quiroga , J A , Richarte , V , Rose , R J , Shin , J , Stallings , M C , Stiby , A I , Wall , T L , Wright , M J , Koot , H M , Paus , T , Hewitt , J K , Ribases , M , Kaprio , J , Boks , M P , Snieder , H , Spector , T , Munafo , M R , Metspalu , A , Gelernter , J , Boomsma , D I , Iacono , W G , Martin , N G , Gillespie , N A , Derks , E M & Vink , J M 2016 , ' Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32330 subjects from the International Cannabis Consortium ' Translational Psychiatry , vol 6 , 769 . DOI: 10.1038/tp.2016.36

Title: Genome-wide association study of lifetime cannabis use based on a large meta-analytic sample of 32330 subjects from the International Cannabis Consortium
Author: Stringer, S.; Minica, C. C.; Verweij, K. J. H.; Mbarek, H.; Bernard, M.; Derringer, J.; van Eijk, K. R.; Isen, J. D.; Loukola, A.; Maciejewski, D. F.; Mihailov, E.; van der Most, P. J.; Sanchez-Mora, C.; Roos, L.; Sherva, R.; Walters, R.; Ware, J. J.; Abdellaoui, A.; Bigdeli, T. B.; Branje, S. J. T.; Brown, S. A.; Bruinenberg, M.; Casas, M.; Esko, T.; Garcia-Martinez, I.; Gordon, S. D.; Harris, J. M.; Hartman, C. A.; Henders, A. K.; Heath, A. C.; Hickie, I. B.; Hickman, M.; Hopfer, C. J.; Hottenga, J. J.; Huizink, A. C.; Irons, D. E.; Kahn, R. S.; Korhonen, T.; Kranzler, H. R.; Krauter, K.; van Lier, P. A. C.; Lubke, G. H.; Madden, P. A. F.; Magi, R.; McGue, M. K.; Medland, S. E.; Meeus, W. H. J.; Miller, M. B.; Montgomery, G. W.; Nivard, M. G.; Nolte, I. M.; Oldehinkel, A. J.; Pausova, Z.; Qaiser, B.; Quaye, L.; Ramos-Quiroga, J. A.; Richarte, V.; Rose, R. J.; Shin, J.; Stallings, M. C.; Stiby, A. I.; Wall, T. L.; Wright, M. J.; Koot, H. M.; Paus, T.; Hewitt, J. K.; Ribases, M.; Kaprio, J.; Boks, M. P.; Snieder, H.; Spector, T.; Munafo, M. R.; Metspalu, A.; Gelernter, J.; Boomsma, D. I.; Iacono, W. G.; Martin, N. G.; Gillespie, N. A.; Derks, E. M.; Vink, J. M.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
University of Helsinki, Institute for Molecular Medicine Finland (FIMM)
University of Helsinki, Clinicum
Belongs to series: Translational Psychiatry
ISSN: 2158-3188
Abstract: Cannabis is the most widely produced and consumed illicit psychoactive substance worldwide. Occasional cannabis use can progress to frequent use, abuse and dependence with all known adverse physical, psychological and social consequences. Individual differences in cannabis initiation are heritable (40-48%). The International Cannabis Consortium was established with the aim to identify genetic risk variants of cannabis use. We conducted a meta-analysis of genome-wide association data of 13 cohorts (N = 32 330) and four replication samples (N = 5627). In addition, we performed a gene-based test of association, estimated single-nucleotide polymorphism (SNP)-based heritability and explored the genetic correlation between lifetime cannabis use and cigarette use using LD score regression. No individual SNPs reached genome-wide significance. Nonetheless, gene-based tests identified four genes significantly associated with lifetime cannabis use: NCAM1, CADM2, SCOC and KCNT2. Previous studies reported associations of NCAM1 with cigarette smoking and other substance use, and those of CADM2 with body mass index, processing speed and autism disorders, which are phenotypes previously reported to be associated with cannabis use.
Peer review status: Peer reviewed
URI: http://hdl.handle.net/10138/161440
Date: 2016-03-29
Subject: ILLICIT DRUG-USE
NICOTINE DEPENDENCE
CANDIDATE GENES
SMOKING-BEHAVIOR
USE INITIATION
ENVIRONMENTAL-INFLUENCES
HAPLOTYPIC VARIANTS
ALCOHOL DEPENDENCE
LINKAGE ANALYSES
USE DISORDERS
3124 Neurology and psychiatry
3142 Public health care science, environmental and occupational health
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