Comparative genomic hybridization analysis of Yersinia enterocolitica and Yersinia pseudotuberculosis identifies genetic traits to elucidate their different ecologies

Show full item record



Permalink

http://hdl.handle.net/10138/161877

Citation

Jaakkola , K , Somervuo , P & Korkeala , H 2015 , ' Comparative genomic hybridization analysis of Yersinia enterocolitica and Yersinia pseudotuberculosis identifies genetic traits to elucidate their different ecologies ' , BioMed Research International , vol. 2015 , 760494 . https://doi.org/10.1155/2015/760494

Title: Comparative genomic hybridization analysis of Yersinia enterocolitica and Yersinia pseudotuberculosis identifies genetic traits to elucidate their different ecologies
Author: Jaakkola, Kaisa; Somervuo, Panu; Korkeala, Hannu
Contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Food Hygiene and Environmental Health
University of Helsinki, Departments of Faculty of Veterinary Medicine
Date: 2015
Language: eng
Number of pages: 12
Belongs to series: BioMed Research International
ISSN: 2314-6133
URI: http://hdl.handle.net/10138/161877
Abstract: Enteropathogenic Yersinia enterocolitica and Yersinia pseudotuberculosis are both etiological agents for intestinal infection known as yersiniosis, but their epidemiology and ecology bearmany differences. Swine are the only known reservoir for Y. enterocolitica 4/O:3 strains, which are the most common cause of human disease, while Y. pseudotuberculosis has been isolated from a variety of sources, including vegetables and wild animals. Infections caused by Y. enterocolitica mainly originate froms wine, but fresh produce has been the source for widespread Y. pseudotuberculosis outbreaks within recent decades. A comparative genomic hybridization analysis with a DNA microarray based on three Yersinia enterocolitica and four Yersinia pseudotuberculosis genomes was conducted to shed light on the genomic differences between enteropathogenic Yersinia. The hybridization results identified Y. pseudotuberculosis strains to carry operons linked with the uptake and utilization of substances not found in living animal tissues but present in soil, plants, and rotting flesh. Y. pseudotuberculosis also harbors a selection of type VI secretion systems targeting other bacteria and eukaryotic cells. These genetic traits are not found in Y. enterocolitica, and it appears that while Y. pseudotuberculosis has many tools beneficial for survival in varied environments, the Y. enterocolitica genome is more streamlined and adapted to their preferred animal reservoir.
Subject: VI SECRETION SYSTEM
HIGH-PATHOGENICITY ISLAND
MOLECULAR CHARACTERIZATION
EXPRESSION TECHNOLOGY
ESCHERICHIA-COLI
BIOTYPE 1B
BACTERIAL
OUTBREAK
PIGS
VIRULENCE
413 Veterinary science
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
760494.pdf 2.029Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record