A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber

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http://hdl.handle.net/10138/162429

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Pallares , J , Senan , O , Guimera , R , Vernet , A , Aguilar-Mogas , A , Vilahur , G , Badimon , L , Sales-Pardo , M & Cito , S 2015 , ' A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber ' Scientific Reports , vol. 5 , 13606 . DOI: 10.1038/srep13606

Title: A comprehensive study on different modelling approaches to predict platelet deposition rates in a perfusion chamber
Author: Pallares, Jordi; Senan, Oriol; Guimera, Roger; Vernet, Anton; Aguilar-Mogas, Antoni; Vilahur, Gemma; Badimon, Lina; Sales-Pardo, Marta; Cito, Salvatore
Contributor: University of Helsinki, Division of Pharmaceutical Chemistry and Technology
Date: 2015-09-22
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/162429
Abstract: Thrombus formation is a multiscale phenomenon triggered by platelet deposition over a protrombotic surface (eg. a ruptured atherosclerotic plaque). Despite the medical urgency for computational tools that aid in the early diagnosis of thrombotic events, the integration of computational models of thrombus formation at different scales requires a comprehensive understanding of the role and limitation of each modelling approach. We propose three different modelling approaches to predict platelet deposition. Specifically, we consider measurements of platelet deposition under blood flow conditions in a perfusion chamber for different time periods (3, 5, 10, 20 and 30 minutes) at shear rates of 212 s(-1), 1390 s(-1) and 1690 s(-1). Our modelling approaches are: i) a model based on the mass-transfer boundary layer theory; ii) a machine-learning approach; and iii) a phenomenological model. The results indicate that the three approaches on average have median errors of 21%, 20.7% and 14.2%, respectively. Our study demonstrates the feasibility of using an empirical data set as a proxy for a real-patient scenario in which practitioners have accumulated data on a given number of patients and want to obtain a diagnosis for a new patient about whom they only have the current observation of a certain number of variables.
Subject: VESSEL WALL
PLAQUE RUPTURE
BLOOD-PLASMA
THROMBUS
FLOW
ADHESION
SHEAR
DYNAMICS
COLLAGEN
SUBENDOTHELIUM
317 Pharmacy
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