Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits

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Randall , J C , Winkler , T W , Kutalik , Z , Berndt , S I , Jackson , A U , Monda , K L , Kilpelaeinen , T O , Esko , T , Maegi , R , Li , S , Workalemahu , T , Feitosa , M F , Croteau-Chonka , D C , Day , F R , Fall , T , Ferreira , T , Gustafsson , S , Locke , A E , Mathieson , I , Scherag , A , Vedantam , S , Wood , A R , Liang , L , Steinthorsdottir , V , Thorleifsson , G , Dermitzakis , E T , Dimas , A S , Karpe , F , Min , J L , Nicholson , G , Clegg , D J , Person , T , Krohn , J P , Bauer , S , Buechler , C , Eisinger , K , Bonnefond , A , Froguel , P , Hottenga , J-J , Prokopenko , I , Waite , L L , Harris , T B , Smith , A V , Shuldiner , A R , McArdle , W L , Caulfield , M J , Munroe , P B , Gronberg , H , Chen , Y-D I , Li , G , Beckmann , J S , Johnson , T , Thorsteinsdottir , U , Teder-Laving , M , Khaw , K-T , Wareham , N J , Zhao , J H , Amin , N , Oostra , B A , Kraja , A T , Province , M A , Cupples , L A , Heard-Costa , N L , Kaprio , J , Ripatti , S , Surakka , I , Collins , F S , Saramies , J , Tuomilehto , J , Jula , A , Salomaa , V , Erdmann , J , Hengstenberg , C , Loley , C , Schunkert , H , Lamina , C , Wichmann , H E , Albrecht , E , Gieger , C , Hicks , A A , Johansson , A , Pramstaller , P P , Kathiresan , S , Speliotes , E K , Penninx , B , Hartikainen , A-L , Jarvelin , M-R , Gyllensten , U , Boomsma , D I , Campbell , H , Wilson , J F , Chanock , S J , Farrall , M , Goel , A , Medina-Gomez , C , Rivadeneira , F , Estrada , K , Uitterlinden , A G , Hofman , A , Zillikens , M C , den Heijer , M , Kiemeney , L A , Maschio , A , Hall , P , Tyrer , J , Teumer , A , Voelzke , H , Kovacs , P , Toenjes , A , Mangino , M , Spector , T D , Hayward , C , Rudan , I , Hall , A S , Samani , N J , Attwood , A P , Sambrook , J G , Hung , J , Palmer , L J , Lokki , M-L , Sinisalo , J-P , Boucher , G , Huikuri , H , Lorentzon , M , Ohlsson , C , Eklund , N , Eriksson , J G , Barlassina , C , Rivolta , C , Nolte , I M , Snieder , H , Van der Klauw , M M , Van Vliet-Ostaptchouk , J V , Gejman , P V , Shi , J , Jacobs , K B , Wang , Z , Bakker , S J L , Leach , I M , Navis , G , van der Harst , P , Martin , N G , Medland , S E , Montgomery , G W , Yang , J , Chasman , D I , Ridker , P M , Rose , L M , Lehtimaki , T , Raitakari , O , Absher , D , Iribarren , C , Basart , H , Hovingh , K G , Hyppoenen , E , Power , C , Anderson , D , Beilby , J P , Hui , J , Jolley , J , Sager , H , Bornstein , S R , Schwarz , P E H , Kristiansson , K , Perola , M , Lindstrom , J , Swift , A J , Uusitupa , M , Atalay , M , Lakka , T A , Rauramaa , R , Bolton , J L , Fowkes , G , Fraser , R M , Price , J F , Fischer , K , KrjutAikov , K , Metspalu , A , Mihailov , E , Langenberg , C , Luan , J , Ong , K K , Chines , P S , Keinanen-Kiukaanniemi , S M , Saaristo , T E , Edkins , S , Franks , P W , Hallmans , G , Shungin , D , Morris , A D , Palmer , C N A , Erbel , R , Moebus , S , Noethen , M M , Pechlivanis , S , Hveem , K , Narisu , N , Hamsten , A , Humphries , S E , Strawbridge , R J , Tremoli , E , Grallert , H , Thorand , B , Illig , T , Koenig , W , Mueller-Nurasyid , M , Peters , A , Boehm , B O , Kleber , M E , Maerz , W , Winkelmann , B R , Kuusisto , J , Laakso , M , Arveiler , D , Cesana , G , Kuulasmaa , K , Virtamo , J , Yarnell , J W G , Kuh , D , Wong , A , Lind , L , de Faire , U , Gigante , B , Magnusson , P K E , Pedersen , N L , Dedoussis , G , Dimitriou , M , Kolovou , G , Kanoni , S , Stirrups , K , Bonnycastle , L L , Njolstad , I , Wilsgaard , T , Ganna , A , Rehnberg , E , Hingorani , A , Kivimäki , M , Kumari , M , Assimes , T L , Barroso , I S , Boehnke , M , Borecki , I B , Deloukas , P , Fox , C S , Frayling , T , Groop , L C , Haritunians , T , Hunter , D , Ingelsson , E , Kaplan , R , Mohlke , K L , O'Connell , J R , Schlessinger , D , Strachan , D P , Stefansson , K , van Duijn , C M , Abecasis , G R , McCarthy , M I , Hirschhorn , J N , Qi , L , Loos , R J F , Lindgren , C M , North , K E , Heid , I M , Consortium , DIAGRAM & Investigators , MAGIC 2013 , ' Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits ' , PLoS Genetics , vol. 9 , no. 6 , e1003500 . https://doi.org/10.1371/journal.pgen.1003500

Title: Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Author: Randall, Joshua C.; Winkler, Thomas W.; Kutalik, Zoltan; Berndt, Sonja I.; Jackson, Anne U.; Monda, Keri L.; Kilpelaeinen, Tuomas O.; Esko, Tonu; Maegi, Reedik; Li, Shengxu; Workalemahu, Tsegaselassie; Feitosa, Mary F.; Croteau-Chonka, Damien C.; Day, Felix R.; Fall, Tove; Ferreira, Teresa; Gustafsson, Stefan; Locke, Adam E.; Mathieson, Iain; Scherag, Andre; Vedantam, Sailaja; Wood, Andrew R.; Liang, Liming; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Dermitzakis, Emmanouil T.; Dimas, Antigone S.; Karpe, Fredrik; Min, Josine L.; Nicholson, George; Clegg, Deborah J.; Person, Thomas; Krohn, Jon P.; Bauer, Sabrina; Buechler, Christa; Eisinger, Kristina; Bonnefond, Amelie; Froguel, Philippe; Hottenga, Jouke-Jan; Prokopenko, Inga; Waite, Lindsay L.; Harris, Tamara B.; Smith, Albert Vernon; Shuldiner, Alan R.; McArdle, Wendy L.; Caulfield, Mark J.; Munroe, Patricia B.; Gronberg, Henrik; Chen, Yii-Der Ida; Li, Guo; Beckmann, Jacques S.; Johnson, Toby; Thorsteinsdottir, Unnur; Teder-Laving, Maris; Khaw, Kay-Tee; Wareham, Nicholas J.; Zhao, Jing Hua; Amin, Najaf; Oostra, Ben A.; Kraja, Aldi T.; Province, Michael A.; Cupples, L. Adrienne; Heard-Costa, Nancy L.; Kaprio, Jaakko; Ripatti, Samuli; Surakka, Ida; Collins, Francis S.; Saramies, Jouko; Tuomilehto, Jaakko; Jula, Antti; Salomaa, Veikko; Erdmann, Jeanette; Hengstenberg, Christian; Loley, Christina; Schunkert, Heribert; Lamina, Claudia; Wichmann, H. Erich; Albrecht, Eva; Gieger, Christian; Hicks, Andrew A.; Johansson, Asa; Pramstaller, Peter P.; Kathiresan, Sekar; Speliotes, Elizabeth K.; Penninx, Brenda; Hartikainen, Anna-Liisa; Jarvelin, Marjo-Riitta; Gyllensten, Ulf; Boomsma, Dorret I.; Campbell, Harry; Wilson, James F.; Chanock, Stephen J.; Farrall, Martin; Goel, Anuj; Medina-Gomez, Carolina; Rivadeneira, Fernando; Estrada, Karol; Uitterlinden, Andre G.; Hofman, Albert; Zillikens, M. Carola; den Heijer, Martin; Kiemeney, Lambertus A.; Maschio, Andrea; Hall, Per; Tyrer, Jonathan; Teumer, Alexander; Voelzke, Henry; Kovacs, Peter; Toenjes, Anke; Mangino, Massimo; Spector, Tim D.; Hayward, Caroline; Rudan, Igor; Hall, Alistair S.; Samani, Nilesh J.; Attwood, Antony Paul; Sambrook, Jennifer G.; Hung, Joseph; Palmer, Lyle J.; Lokki, Marja-Liisa; Sinisalo, Juha-Pekka; Boucher, Gabrielle; Huikuri, Heikki; Lorentzon, Mattias; Ohlsson, Claes; Eklund, Niina; Eriksson, Johan G.; Barlassina, Cristina; Rivolta, Carlo; Nolte, Ilja M.; Snieder, Harold; Van der Klauw, Melanie M.; Van Vliet-Ostaptchouk, Jana V.; Gejman, Pablo V.; Shi, Jianxin; Jacobs, Kevin B.; Wang, Zhaoming; Bakker, Stephan J. L.; Leach, Irene Mateo; Navis, Gerjan; van der Harst, Pim; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Yang, Jian; Chasman, Daniel I.; Ridker, Paul M.; Rose, Lynda M.; Lehtimaki, Terho; Raitakari, Olli; Absher, Devin; Iribarren, Carlos; Basart, Hanneke; Hovingh, Kees G.; Hyppoenen, Elina; Power, Chris; Anderson, Denise; Beilby, John P.; Hui, Jennie; Jolley, Jennifer; Sager, Hendrik; Bornstein, Stefan R.; Schwarz, Peter E. H.; Kristiansson, Kati; Perola, Markus; Lindstrom, Jaana; Swift, Amy J.; Uusitupa, Matti; Atalay, Mustafa; Lakka, Timo A.; Rauramaa, Rainer; Bolton, Jennifer L.; Fowkes, Gerry; Fraser, Ross M.; Price, Jackie F.; Fischer, Krista; KrjutAikov, Kaarel; Metspalu, Andres; Mihailov, Evelin; Langenberg, Claudia; Luan, Jian'an; Ong, Ken K.; Chines, Peter S.; Keinanen-Kiukaanniemi, Sirkka M.; Saaristo, Timo E.; Edkins, Sarah; Franks, Paul W.; Hallmans, Goran; Shungin, Dmitry; Morris, Andrew David; Palmer, Colin N. A.; Erbel, Raimund; Moebus, Susanne; Noethen, Markus M.; Pechlivanis, Sonali; Hveem, Kristian; Narisu, Narisu; Hamsten, Anders; Humphries, Steve E.; Strawbridge, Rona J.; Tremoli, Elena; Grallert, Harald; Thorand, Barbara; Illig, Thomas; Koenig, Wolfgang; Mueller-Nurasyid, Martina; Peters, Annette; Boehm, Bernhard O.; Kleber, Marcus E.; Maerz, Winfried; Winkelmann, Bernhard R.; Kuusisto, Johanna; Laakso, Markku; Arveiler, Dominique; Cesana, Giancarlo; Kuulasmaa, Kari; Virtamo, Jarmo; Yarnell, John W. G.; Kuh, Diana; Wong, Andrew; Lind, Lars; de Faire, Ulf; Gigante, Bruna; Magnusson, Patrik K. E.; Pedersen, Nancy L.; Dedoussis, George; Dimitriou, Maria; Kolovou, Genovefa; Kanoni, Stavroula; Stirrups, Kathleen; Bonnycastle, Lori L.; Njolstad, Inger; Wilsgaard, Tom; Ganna, Andrea; Rehnberg, Emil; Hingorani, Aroon; Kivimäki, Mika; Kumari, Meena; Assimes, Themistocles L.; Barroso, Ine S.; Boehnke, Michael; Borecki, Ingrid B.; Deloukas, Panos; Fox, Caroline S.; Frayling, Timothy; Groop, Leif C.; Haritunians, Talin; Hunter, David; Ingelsson, Erik; Kaplan, Robert; Mohlke, Karen L.; O'Connell, Jeffrey R.; Schlessinger, David; Strachan, David P.; Stefansson, Kari; van Duijn, Cornelia M.; Abecasis, Goncalo R.; McCarthy, Mark I.; Hirschhorn, Joel N.; Qi, Lu; Loos, Ruth J. F.; Lindgren, Cecilia M.; North, Kari E.; Heid, Iris M.; Consortium, DIAGRAM; Investigators, MAGIC
Contributor: University of Helsinki, Hjelt Institute (-2014)
University of Helsinki, Hjelt Institute (-2014)
University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Department of Public Health
University of Helsinki, Haartman Institute (-2014)
University of Helsinki, Kardiologian yksikkö
University of Helsinki, Clinicum
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2013-06-01
Language: eng
Number of pages: 19
Belongs to series: PLoS Genetics
ISSN: 1553-7404
URI: http://hdl.handle.net/10138/162522
Subject: 3111 Biomedicine
3121 General medicine, internal medicine and other clinical medicine
515 Psychology
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