Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated with Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents with Type 1 Diabetes

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http://urn.fi/URN:NBN:fi:hulib-201606092278
Title: Positivity for Zinc Transporter 8 Autoantibodies at Diagnosis Is Subsequently Associated with Reduced β-Cell Function and Higher Exogenous Insulin Requirement in Children and Adolescents with Type 1 Diabetes
Author: Juusola, Matilda; Parkkola, Anna; Härkönen, Taina; Siljander, Heli; Ilonen, Jorma; Åkerblom, Hans; Knip, Mikael
Contributor: University of Helsinki, Faculty of Medicine
Publisher: Helsingfors universitet
Date: 2015
Language: eng
URI: http://urn.fi/URN:NBN:fi:hulib-201606092278
http://hdl.handle.net/10138/163642
Thesis level: master's thesis
Discipline: Paediatrics
Lastentaudit
Barnsjukdomar
Abstract: RESEARCH DESIGN AND METHODS We set out to define the relationship between autoantibodies against zinc transporter 8 (ZnT8) and other diabetes-associated autoantibodies, HLA DR-DQ alleles and metabolic status in Finnish children with newly diagnosed type 1 diabetes (n=723). Metabolic status was monitored by plasma glucose and pH at diagnosis, and through a 2-year follow-up of C-peptide concentrations, daily insulin dose and GHb levels. RESULTS ZnT8A-positivity was detected in 530 children (73%). Positivity for ZnT8A was associated with older age (median 8.9 vs. 8.2 years, P=0.002) and more frequent ketoacidosis (24% vs. 15%; P=0.013). Children carrying the HLA DR3 allele were less often ZnT8A-positive (66% vs. 77%, P=0.002) than others. ZnT8A-positive children had lower serum C-peptide concentrations (P=0.008) and higher insulin doses (P=0.012) over time than their ZnT8A-negative peers. CONCLUSIONS Positivity for ZnT8A at diagnosis seems to reflect a more aggressive disease process both before and after diagnosis.
Subject: ZnT8A
HbA1c
vasta-aineet
C-peptidi
insuliini
diabetes


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