Similar Antibody Levels in 3-Year-Old Children Vaccinated Against Measles, Mumps, and Rubella at the Age of 12 Months or 18 Months

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Kontio , M , Palmu , A A , Syrjanen , R K , Lahdenkari , M , Ruokokoski , E , Davidkin , I , Vaarala , O & Melin , M 2016 , ' Similar Antibody Levels in 3-Year-Old Children Vaccinated Against Measles, Mumps, and Rubella at the Age of 12 Months or 18 Months ' , Journal of Infectious Diseases , vol. 213 , no. 12 , pp. 2005-2013 . https://doi.org/10.1093/infdis/jiw058

Title: Similar Antibody Levels in 3-Year-Old Children Vaccinated Against Measles, Mumps, and Rubella at the Age of 12 Months or 18 Months
Author: Kontio, Mia; Palmu, Arto A.; Syrjanen, Ritva K.; Lahdenkari, Mika; Ruokokoski, Esa; Davidkin, Irja; Vaarala, Outi; Melin, Merit
Contributor: University of Helsinki, Clinicum
Date: 2016-06-15
Language: eng
Number of pages: 9
Belongs to series: Journal of Infectious Diseases
ISSN: 0022-1899
URI: http://hdl.handle.net/10138/164662
Abstract: Background. Measles-mumps-rubella (MMR) vaccinations have been offered to Finnish children at 14-18 months and 6 years of age. In May 2011, the recommended age for the first vaccine dose was lowered to 12 months because of the European measles epidemic. Methods. Fingertip capillary blood samples were collected from 3-year-old Finnish children vaccinated once with MMR vaccine at 11-19 months of age. The immunoglobulin G (IgG) antibodies to all 3 MMR antigens were measured with enzyme-linked immunosorbent assay. Neutralizing antibodies and the avidity of antibodies were measured for measles virus. Results. From April through October 2013, 187 children were enrolled. Equally high proportions of the samples were seropositive for measles virus, mumps virus, or rubella virus antibodies, and there were no significant differences in the IgG antibody concentrations in children vaccinated at 11-13 months of age, compared with those vaccinated at 17-19 months of age. However, among children vaccinated at 11-13 months of age, boys had lower antibody concentrations than girls. Neutralizing measles virus antibody titers were above the threshold for protective immunity in all 78 samples analyzed. The measles virus antibody avidity indexes were high for all children. Conclusions. MMR induces similar antibody responses in 12-month-old children as compared to 18-month-old children, but in boys increasing age appears to improve the antibody responses.
Subject: MMR
measles
mumps
rubella
vaccine
antibody
immune response
immunization
vaccination schedule
ACQUIRED MATERNAL ANTIBODIES
IMMUNE-RESPONSES
NEUTRALIZATION TEST
MMR VACCINE
HIGHER RISK
IMMUNIZATION
INFANTS
IMMUNOGENICITY
ELIMINATION
PERSISTENCE
3121 General medicine, internal medicine and other clinical medicine
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