Altered cardiorespiratory response to exercise in overweight and obese women with polycystic ovary syndrome

Show full item record



Permalink

http://hdl.handle.net/10138/164727

Citation

Rissanen , A-P E , Koskela-Koivisto , T , Hägglund , H , Koponen , A S , Aho , J M , Pöyhönen-Alho , M , Tiitinen , A , Tikkanen , H O & Peltonen , J E 2016 , ' Altered cardiorespiratory response to exercise in overweight and obese women with polycystic ovary syndrome ' , Physiological Reports , vol. 4 , no. 4 , e12719 . https://doi.org/10.14814/phy2.12719

Title: Altered cardiorespiratory response to exercise in overweight and obese women with polycystic ovary syndrome
Author: Rissanen, Antti-Pekka E.; Koskela-Koivisto, Tiina; Hägglund, Harriet; Koponen, Anne S.; Aho, Jyrki M.; Pöyhönen-Alho, Maritta; Tiitinen, Aila; Tikkanen, Heikki O.; Peltonen, Juha E.
Contributor: University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Department of Obstetrics and Gynecology
University of Helsinki, Clinicum
University of Helsinki, Clinicum
University of Helsinki, Clinicum
Date: 2016-02
Language: eng
Number of pages: 12
Belongs to series: Physiological Reports
ISSN: 2051-817X
URI: http://hdl.handle.net/10138/164727
Abstract: In polycystic ovary syndrome (PCOS), cardiovascular risk is increased. Peak O2 uptake (V˙O2peak) predicts the cardiovascular risk. We were the first to examine the contribution of systemic O2 delivery and arteriovenous O2 difference to V˙O2peak in overweight and obese women with PCOS. Fifteen overweight or obese PCOS women and 15 age-, anthropometry-, and physical activity-matched control women performed a maximal incremental cycling exercise test. Alveolar gas exchange (volume turbine and mass spectrometry), arterial O2 saturation (pulse oximetry), and cardiac output (CO) (impedance cardiography) were monitored. Hb concentration was determined. Arterial O2 content and arteriovenous O2 difference (C(a-v)O2) (Fick equation) were calculated. Insulin resistance was evaluated by homeostasis model assessment (HOMA-IR). PCOS women had lower V˙O2peak than controls (40 ± 6 vs. 46 ± 5 mL/min/kg fat-free mass [FFM], P = 0.011). Arterial O2 content was similarly maintained in the groups throughout the exercise test (P > 0.05). Linear regression analysis revealed a pronounced response of CO to increasing V˙O2 in PCOS women during the exercise test: A ∆CO/∆V˙O2 slope was steeper in PCOS women than in controls (β = 5.84 vs. β = 5.21, P = 0.004). Eventually, the groups attained similar peak CO and peak CO scaled to FFM (P > 0.05). Instead, C(a-v)O2 at peak exercise was lower in PCOS women than in controls (13.2 ± 1.6 vs. 14.8 ± 2.4 mL O2/100 mL blood, P = 0.044). HOMA-IR was similar in the groups (P > 0.05). The altered cardiorespiratory responses to exercise in overweight and obese PCOS women indicate that PCOS per se is associated with alterations in peripheral adjustments to exercise rather than with limitations of systemic O2 delivery.
Subject: 3123 Gynaecology and paediatrics
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
PHY2_4_e12719.pdf 281.5Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record