Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal

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Bui , T P N , Ritari , J , Boeren , S , de Waard , P , Plugge , C M & de Vos , W M 2015 , ' Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal ' , Nature Communications , vol. 6 , 10062 . https://doi.org/10.1038/ncomms10062

Title: Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal
Author: Bui, Thi Phuong Nam; Ritari, Jarmo; Boeren, Sjef; de Waard, Pieter; Plugge, Caroline M.; de Vos, Willem M.
Other contributor: University of Helsinki, Departments of Faculty of Veterinary Medicine
University of Helsinki, Medicum








Date: 2015-12
Language: eng
Number of pages: 10
Belongs to series: Nature Communications
ISSN: 2041-1723
DOI: https://doi.org/10.1038/ncomms10062
URI: http://hdl.handle.net/10138/165275
Abstract: Human intestinal bacteria produce butyrate, which has signalling properties and can be used as energy source by enterocytes thus influencing colonic health. However, the pathways and the identity of bacteria involved in this process remain unclear. Here we describe the isolation from the human intestine of Intestinimonas strain AF211, a bacterium that can convert lysine stoichiometrically into butyrate and acetate when grown in a synthetic medium. Intestinimonas AF211 also converts the Amadori product fructoselysine, which is abundantly formed in heated foods via the Maillard reaction, into butyrate. The butyrogenic pathway includes a specific CoA transferase that is overproduced during growth on lysine. Bacteria related to Intestinimonas AF211 as well as the genetic coding capacity for fructoselysine conversion are abundantly present in colonic samples from some healthy human subjects. Our results indicate that protein can serve as a source of butyrate in the human colon, and its conversion by Intestinimonas AF211 and related butyrogens may protect the host from the undesired side effects of Amadori reaction products.
Subject: HUMAN LARGE-INTESTINE
CLOSTRIDIUM-ACETOBUTYLICUM
FUSOBACTERIUM-NUCLEATUM
FERMENTING CLOSTRIDIUM
ANAEROBIC-BACTERIA
ESCHERICHIA-COLI
COA-TRANSFERASE
SP NOV.
MICROBIOTA
PATHWAY
3111 Biomedicine
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