rs2735383, located at a microRNA binding site in the 3 ' UTR of NBS1, is not associated with breast cancer risk

Show full item record



Permalink

http://hdl.handle.net/10138/170152

Citation

Liu , J , Loncar , I , Collee , J M , Bolla , M K , Dennis , J , Michailidou , K , Wang , Q , Andrulis , I L , Barile , M , Beckmann , M W , Behrens , S , Benitez , J , Blomqvist , C , Boeckx , B , Bogdanova , N V , Bojesen , S E , Brauch , H , Brennan , P , Brenner , H , Broeks , A , Burwinkel , B , Chang-Claude , J , Chen , S-T , Chenevix-Trench , G , Cheng , C Y , Choi , J-Y , Couch , F J , Cox , A , Cross , S S , Cuk , K , Czene , K , Doerk , T , Dos-Santos-Silva , I , Fasching , P A , Figueroa , J , Flyger , H , Garcia-Closas , M , Giles , G G , Glendon , G , Goldberg , M S , Gonzalez-Neira , A , Guenel , P , Haiman , C A , Hamann , U , Hart , S N , Hartman , M , Hatse , S , Hopper , J L , Ito , H , Nevanlinna , H & NBCS Collaborators 2016 , ' rs2735383, located at a microRNA binding site in the 3 ' UTR of NBS1, is not associated with breast cancer risk ' Scientific Reports , vol. 6 , 36874 . DOI: 10.1038/srep36874

Title: rs2735383, located at a microRNA binding site in the 3 ' UTR of NBS1, is not associated with breast cancer risk
Author: Liu, Jingjing; Loncar, Ivona; Collee, J. Margriet; Bolla, Manjeet K.; Dennis, Joe; Michailidou, Kyriaki; Wang, Qin; Andrulis, Irene L.; Barile, Monica; Beckmann, Matthias W.; Behrens, Sabine; Benitez, Javier; Blomqvist, Carl; Boeckx, Bram; Bogdanova, Natalia V.; Bojesen, Stig E.; Brauch, Hiltrud; Brennan, Paul; Brenner, Hermann; Broeks, Annegien; Burwinkel, Barbara; Chang-Claude, Jenny; Chen, Shou-Tung; Chenevix-Trench, Georgia; Cheng, Ching Y.; Choi, Ji-Yeob; Couch, Fergus J.; Cox, Angela; Cross, Simon S.; Cuk, Katarina; Czene, Kamila; Doerk, Thilo; Dos-Santos-Silva, Isabel; Fasching, Peter A.; Figueroa, Jonine; Flyger, Henrik; Garcia-Closas, Montserrat; Giles, Graham G.; Glendon, Gord; Goldberg, Mark S.; Gonzalez-Neira, Anna; Guenel, Pascal; Haiman, Christopher A.; Hamann, Ute; Hart, Steven N.; Hartman, Mikael; Hatse, Sigrid; Hopper, John L.; Ito, Hidemi; Nevanlinna, Heli; NBCS Collaborators
Contributor: University of Helsinki, Department of Oncology
University of Helsinki, Department of Obstetrics and Gynegology
Date: 2016-11-15
Language: eng
Number of pages: 13
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/170152
Abstract: NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genotyped rs2735383 in 1,170 familial non-BRCA1/2 breast cancer cases and 1,077 controls using PCR-based restriction fragment length polymorphism (RFLP-PCR) analysis, but found no association between rs2735383CC and breast cancer risk (OR = 1.214, 95% CI = 0.936-1.574, P = 0.144). Because we could not exclude a small effect size due to a limited sample size, we further analyzed imputed rs2735383 genotypes (r(2) > 0.999) of 47,640 breast cancer cases and 46,656 controls from the Breast Cancer Association Consortium (BCAC). However, rs2735383CC was not associated with overall breast cancer risk in European (OR = 1.014, 95% CI = 0.969-1.060, P = 0.556) nor in Asian women (OR = 0.998, 95% CI = 0.905-1.100, P = 0.961). Subgroup analyses by age, age at menarche, age at menopause, menopausal status, number of pregnancies, breast feeding, family history and receptor status also did not reveal a significant association. This study therefore does not support the involvement of the genotype at NBS1 rs2735383 in breast cancer susceptibility.
Subject: GENOME-WIDE ASSOCIATION
DOUBLE-STRAND BREAKS
GLU185GLN POLYMORPHISM
FUNCTIONAL POLYMORPHISM
PATHWAY GENES
LUNG-CANCER
METAANALYSIS
SUSCEPTIBILITY
REPAIR
POPULATIONS
3122 Cancers
3123 Gynaecology and paediatrics
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
srep36874.pdf 670.0Kb PDF View/Open

This item appears in the following Collection(s)

Show full item record