Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases : Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?

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Mannistö , P T & Garcia-Horsman , J A 2017 , ' Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases : Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins? ' , Frontiers in aging neuroscience , vol. 9 , 27 . https://doi.org/10.3389/fnagi.2017.00027

Title: Mechanism of Action of Prolyl Oligopeptidase (PREP) in Degenerative Brain Diseases : Has Peptidase Activity Only a Modulatory Role on the Interactions of PREP with Proteins?
Author: Mannistö, Pekka T.; Garcia-Horsman, J. Arturo
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Faculty of Pharmacy
Date: 2017-02-14
Language: eng
Number of pages: 10
Belongs to series: Frontiers in aging neuroscience
ISSN: 1663-4365
URI: http://hdl.handle.net/10138/177556
Abstract: In the aging brain, the correct balance of neural transmission and its regulation is of particular significance, and neuropeptides have a significant role. Prolyl oligopeptidase (PREP) is a protein highly expressed in brain, and evidence indicates that it is related to aging and in neurodegenration. Although PREP is regarded as a peptidase, the physiological substrates in the brain have not been defined, and after intense research, the molecular mechanisms where this protein is involved have not been defined. We propose that PREP functions as a regulator of other proteins though peptide gated direct interaction. We speculate that, at least in some processes where PREP has shown to be relevant, the peptidase activity is only a consequence of the interactions, and not the main physiological activity.
Subject: prolyl oligopeptidase
neuropeptides
aging neuroscience
neurodegeneration
proten-protein interactions
INHIBITING ENZYMATIC CLEAVAGE
THYROTROPIN-RELEASING-HORMONE
BETA-PROPELLER DOMAIN
ENDOPEPTIDASE INHIBITOR
RAT-BRAIN
ALPHA-SYNUCLEIN
GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
SPATIAL MEMORY
SUBSTANCE-P
PRECURSOR ALPHA(2)-ANTIPLASMIN
3112 Neurosciences
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