A miniaturised 3D printed polypropylene reactor for online reaction analysis by mass spectrometry

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http://hdl.handle.net/10138/189720

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Scotti , G , Nilsson , S M E , Haapala , M , Pöhö , P , Boije af Gennäs , G , Yli-Kauhaluoma , J & Kotiaho , T 2017 , ' A miniaturised 3D printed polypropylene reactor for online reaction analysis by mass spectrometry ' , Reaction Chemistry & Engineering , vol. 2 , no. 3 , pp. 299-303 . https://doi.org/10.1039/c7re00015d

Title: A miniaturised 3D printed polypropylene reactor for online reaction analysis by mass spectrometry
Author: Scotti, Gianmario; Nilsson, Sofia M. E.; Haapala, Markus; Pöhö, Päivi; Boije af Gennäs, Gustav; Yli-Kauhaluoma, Jari; Kotiaho, Tapio
Contributor: University of Helsinki, Faculty of Pharmacy
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Division of Pharmaceutical Chemistry and Technology
University of Helsinki, Faculty of Pharmacy
University of Helsinki, Pharmaceutical Design and Discovery group
University of Helsinki, Pharmaceutical Design and Discovery group
University of Helsinki, Drug Research Program
Date: 2017-06-01
Language: eng
Number of pages: 5
Belongs to series: Reaction Chemistry & Engineering
ISSN: 2058-9883
URI: http://hdl.handle.net/10138/189720
Abstract: A miniaturised polypropylene reactor was fabricated by 3D printing using fused deposition modeling. A stainless steel nanoelectrospray ionisation capillary and a magnetic stir bar were integrated into the reactor during the printing process. The integrated nanoelectrospray ionisation capillary allows direct sampling of a reaction solution without external pumping. It also allows ionisation of the analytes. Therefore, very rapid online mass spectrometric chemical reaction monitoring is possible. Operation of the miniaturised reactor is shown by the online nanoelectrospray mass spectrometry characterisation of a Diels–Alder reaction and the subsequent retro Diels–Alder reaction.
Subject: 116 Chemical sciences
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