A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients

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http://hdl.handle.net/10138/198891

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Roininen , S , Laine , O , Kauppila , M , Vesanen , M , Ramet , M , Sinisalo , M , Jantunen , E , Saily , M , Räty , R , Elonen , E & Wartiovaara-Kautto , U 2017 , ' A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients ' , Cancer medicine , vol. 6 , no. 6 , pp. 1275-1285 . https://doi.org/10.1002/cam4.1094

Title: A minor role of asparaginase in predisposing to cerebral venous thromboses in adult acute lymphoblastic leukemia patients
Author: Roininen, Saara; Laine, Outi; Kauppila, Marjut; Vesanen, Marko; Ramet, Maria; Sinisalo, Marjatta; Jantunen, Esa; Saily, Marjaana; Räty, Riikka; Elonen, Erkki; Wartiovaara-Kautto, Ulla
Contributor: University of Helsinki, Department of Oncology
University of Helsinki, Hematologian yksikkö
University of Helsinki, Department of Medicine
University of Helsinki, Clinicum
Date: 2017-06
Language: eng
Number of pages: 11
Belongs to series: Cancer medicine
ISSN: 2045-7634
URI: http://hdl.handle.net/10138/198891
Abstract: Cerebral venous thrombosis (CVT) covers up to a third of all venous thromboses (VTs) detected in patients with acute lymphoblastic leukemia (ALL). It usually hampers patients' lives and may also endanger efficient leukemia treatment. Although many factors have been suggested to account for an elevated risk of VTs in patients with ALL, there still is a lack of studies focusing on CVTs and especially in the setting of adult ALL patients. We studied in our retrospective population-based cohort the occurrence, characteristics, as well as risk factors for VTs in 186 consecutively diagnosed Finnish adult ALL patients treated with a national pediatric-inspired treatment protocol ALL2000. In the risk factor analyses for VTs we found a distinction of the characteristics of the patients acquiring CVT from those with other kinds of VTs or without thrombosis. In contrast to previous studies we were also able to compare the effects of asparaginase in relation to CVT occurrence. Notably, more than half of the CVTs were diagnosed prior the administration of asparaginase which accentuates the role of other risk factors on the pathophysiology of CVT compared to truncal or central venous line (CVL) VTs in adult ALL patients.
Subject: Acute lymphoblastic leukemia
asparaginase
cerebral venous thrombosis
risk factors
RISK-FACTORS
INDUCTION CHEMOTHERAPY
CHILDREN
THROMBOEMBOLISM
COAGULATION
MULTICENTER
DIAGNOSIS
COHORT
3122 Cancers
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