GABA actions and ionic plasticity in epilepsy

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http://hdl.handle.net/10138/216730

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Kaila , K , Ruusuvuori , E , Seja , P , Voipio , J & Puskarjov , M 2014 , ' GABA actions and ionic plasticity in epilepsy ' , Current Opinion in Neurobiology , vol. 26 , pp. 34-41 . https://doi.org/10.1016/j.conb.2013.11.004

Title: GABA actions and ionic plasticity in epilepsy
Author: Kaila, Kai; Ruusuvuori, Eva; Seja, Patricia; Voipio, Juha; Puskarjov, Martin
Contributor organization: Biosciences
Kai Kaila / Principal Investigator
Neuroscience Center
Physiology and Neuroscience (-2020)
Juha Voipio / Principal Investigator
Laboratory of Neurobiology
Date: 2014-06
Language: eng
Number of pages: 8
Belongs to series: Current Opinion in Neurobiology
ISSN: 0959-4388
DOI: https://doi.org/10.1016/j.conb.2013.11.004
URI: http://hdl.handle.net/10138/216730
Abstract: Concepts of epilepsy, based on a simple change in neuronal excitation/inhibition balance, have subsided in face of recent insights into the large diversity and context-dependence of signaling mechanisms at the molecular, cellular and neuronal network level. GABAergic transmission exerts both seizure-suppressing and seizure-promoting actions. These two roles are prone to short-term and long-term alterations, evident both during epileptogenesis and during individual epileptiform events. The driving force of GABAergic currents is controlled by ion-regulatory molecules such as the neuronal K-Cl cotransporter KCC2 and cytosolic carbonic anhydrases. Accumulating evidence suggests that neuronal ion regulation is highly plastic, thereby contributing to the multiple roles ascribed to GABAergic signaling during epileptogenesis and epilepsy.
Subject: TEMPORAL-LOBE EPILEPSY
CL-COTRANSPORTER KCC2
CATION-CHLORIDE COTRANSPORTERS
RAT HIPPOCAMPAL SLICE
STATUS EPILEPTICUS
SEIZURE PROPAGATION
PYRAMIDAL NEURONS
DOWN-REGULATION
NERVOUS-SYSTEM
IN-VITRO
3112 Neurosciences
Peer reviewed: Yes
Rights: cc_by
Usage restriction: openAccess
Self-archived version: publishedVersion


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