CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs

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Schatton , D , Pla-Martin , D , Marx , M-C , Hansen , H , Mourier , A , Nemazanyy , I , Pessia , A , Zentis , P , Corona , T , Kondylis , V , Barth , E , Schauss , A C , Velagapudi , V & Rugarli , E I 2017 , ' CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs ' , Journal of Cell Biology , vol. 216 , no. 3 , pp. 675-693 . https://doi.org/10.1083/jcb.201607019

Title: CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs
Author: Schatton, Désirée; Pla-Martin, David; Marx, Marie-Charlotte; Hansen, Henriette; Mourier, Arnaud; Nemazanyy, Ivan; Pessia, Alberto; Zentis, Peter; Corona, Teresa; Kondylis, Vangelis; Barth, Esther; Schauss, Astrid C.; Velagapudi, Vidya; Rugarli, Elena I.
Contributor: University of Helsinki, Institute for Molecular Medicine Finland
University of Helsinki, Institute for Molecular Medicine Finland
Date: 2017-03-06
Language: eng
Number of pages: 19
Belongs to series: Journal of Cell Biology
ISSN: 0021-9525
URI: http://hdl.handle.net/10138/224151
Abstract: Mitochondria are essential organelles that host crucial metabolic pathways and produce adenosine triphosphate. The mitochondrial proteome is heterogeneous among tissues and can dynamically change in response to different metabolic conditions. Although the transcriptional programs that govern mitochondrial biogenesis and respiratory function are well known, posttranscriptional regulatory mechanisms remain unclear. In this study, we show that the cytosolic RNA-binding protein clustered mitochondria homologue (CLUH) regulates the expression of a mitochondrial protein network supporting key metabolic programs required under nutrient deprivation. CLUH exerts its function by controlling the stability and translation of target messenger RNAs. In the absence of Cluh, mitochondria are severely depleted of crucial enzymes involved in catabolic energy-converting pathways. CLUH preserves oxidative mitochondrial function and glucose homeostasis, thus preventing death at the fetal–neonatal transition. In the adult liver, CLUH ensures maximal respiration capacity and the metabolic response to starvation. Our results shed new light on the posttranscriptional mechanisms controlling the expression of mitochondrial proteins and suggest novel strategies to tailor mitochondrial function to physiological and pathological conditions.
Subject: 1182 Biochemistry, cell and molecular biology
METABOLOMICS
CLUH
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