Mitogenome Sequencing in the Genus Camelus Reveals Evidence for Purifying Selection and Long-term Divergence between Wild and Domestic Bactrian Camels

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Mohandesan , E , Fitak , R R , Corander , J , Yadamsuren , A , Chuluunbat , B , Abdelhadi , O , Raziq , A , Nagy , P , Stalder , G , Walzer , C , Faye , B & Burger , P A 2017 , ' Mitogenome Sequencing in the Genus Camelus Reveals Evidence for Purifying Selection and Long-term Divergence between Wild and Domestic Bactrian Camels ' , Scientific Reports , vol. 7 , 9970 . https://doi.org/10.1038/s41598-017-08995-8

Title: Mitogenome Sequencing in the Genus Camelus Reveals Evidence for Purifying Selection and Long-term Divergence between Wild and Domestic Bactrian Camels
Author: Mohandesan, Elmira; Fitak, Robert R.; Corander, Jukka; Yadamsuren, Adiya; Chuluunbat, Battsetseg; Abdelhadi, Omer; Raziq, Abdul; Nagy, Peter; Stalder, Gabrielle; Walzer, Chris; Faye, Bernard; Burger, Pamela A.
Contributor: University of Helsinki, Department of Mathematics and Statistics
Date: 2017-08-30
Language: eng
Number of pages: 12
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/224213
Abstract: The genus Camelus is an interesting model to study adaptive evolution in the mitochondrial genome, as the three extant Old World camel species inhabit hot and low-altitude as well as cold and high-altitude deserts. We sequenced 24 camel mitogenomes and combined them with three previously published sequences to study the role of natural selection under different environmental pressure, and to advance our understanding of the evolutionary history of the genus Camelus. We confirmed the heterogeneity of divergence across different components of the electron transport system. Lineage-specific analysis of mitochondrial protein evolution revealed a significant effect of purifying selection in the concatenated protein-coding genes in domestic Bactrian camels. The estimated dN/dS
Subject: CYTOCHROME-C-OXIDASE
MITOCHONDRIAL-DNA
POSITIVE SELECTION
NATURAL-SELECTION
COMPARATIVE GENOMICS
MOLECULAR EVOLUTION
FUNCTIONAL DOMAINS
STATISTICAL TESTS
POPULATION-GROWTH
PROTEIN EVOLUTION
1181 Ecology, evolutionary biology
1183 Plant biology, microbiology, virology
112 Statistics and probability
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