Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data : Data from the Osteoarthritis Initiative

Show full item record



Permalink

http://hdl.handle.net/10138/224248

Citation

Liukkonen , M K , Mononen , M E , Klets , O , Arokoski , J P , Saarakkala , S & Korhonen , R K 2017 , ' Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data : Data from the Osteoarthritis Initiative ' , Scientific Reports , vol. 7 , 9177 . https://doi.org/10.1038/s41598-017-09013-7

Title: Simulation of Subject-Specific Progression of Knee Osteoarthritis and Comparison to Experimental Follow-up Data : Data from the Osteoarthritis Initiative
Author: Liukkonen, Mimmi K.; Mononen, Mika E.; Klets, Olesya; Arokoski, Jari P.; Saarakkala, Simo; Korhonen, Rami K.
Contributor: University of Helsinki, Clinicum
Date: 2017-08-23
Language: eng
Number of pages: 14
Belongs to series: Scientific Reports
ISSN: 2045-2322
URI: http://hdl.handle.net/10138/224248
Abstract: Economic costs of osteoarthritis (OA) are considerable. However, there are no clinical tools to predict the progression of OA or guide patients to a correct treatment for preventing OA. We tested the ability of our cartilage degeneration algorithm to predict the subject-specific development of OA and separate groups with different OA levels. The algorithm was able to predict OA progression similarly with the experimental follow-up data and separate subjects with radiographical OA (Kellgren-Lawrence (KL) grade 2 and 3) from healthy subjects (KL0). Maximum degeneration and degenerated volumes within cartilage were significantly higher (p <0.05) in OA compared to healthy subjects, KL3 group showing the highest degeneration values. Presented algorithm shows a great potential to predict subjectspecific progression of knee OA and has a clinical potential by simulating the effect of interventions on the progression of OA, thus helping decision making in an attempt to delay or prevent further OA symptoms.
Subject: 3D FINITE-ELEMENT
ARTICULAR-CARTILAGE
PHYSICAL-ACTIVITY
COLLAGEN NETWORK
UNITED-STATES
IN-VIVO
JOINT
MRI
STRESSES
MENISCUS
3121 General medicine, internal medicine and other clinical medicine
Rights:


Files in this item

Total number of downloads: Loading...

Files Size Format View
s41598_017_09013_7.pdf 4.590Mb PDF View/Open

This item appears in the following Collection(s)

Show full item record