Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study

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Nordal , E , Rypdal , V , Christoffersen , T , Aalto , K , Berntson , L , Fasth , A , Herlin , T , Nielsen , S , Peltoniemi , S , Straume , B , Zak , M , Rygg , M & Nordic Study Grp Pediat Rheumatolo 2017 , ' Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study ' , Pediatric Rheumatology Online Journal , vol. 15 , 66 . https://doi.org/10.1186/s12969-017-0195-8

Title: Incidence and predictors of Uveitis in juvenile idiopathic arthritis in a Nordic long-term cohort study
Author: Nordal, Ellen; Rypdal, Veronika; Christoffersen, Terje; Aalto, Kristiina; Berntson, Lillemor; Fasth, Anders; Herlin, Troels; Nielsen, Susan; Peltoniemi, Suvi; Straume, Bjorn; Zak, Marek; Rygg, Marite; Nordic Study Grp Pediat Rheumatolo
Contributor: University of Helsinki, Children's Hospital
University of Helsinki, Children's Hospital
Date: 2017-08-18
Language: eng
Number of pages: 8
Belongs to series: Pediatric Rheumatology Online Journal
ISSN: 1546-0096
URI: http://hdl.handle.net/10138/224273
Abstract: Background: The incidence of uveitis associated with juvenile idiopathic arthritis (JIA) varies around the world. Our aim was to investigate the incidence and predictors of uveitis in a Nordic population-based cohort. Methods: Consecutive JIA cases from defined geographical areas in Denmark, Finland, Sweden and Norway with disease onset between January 1997 to June 2000 were followed for median 98 months in this prospective longitudinal cohort study. Potential clinical and immunological predictors of uveitis were identified with logistic regression analysis. Results: Uveitis occurred in 89 (20.5%) of the 435 children with regular ophtalmologic follow-up among the 500 included. Chronic asymptomatic uveitis developed in 80 and acute symptomatic uveitis in 9 children. Uveitis developed at a median interval of 0.8 (range - 4.7 to 9.4) years after onset of arthritis. Predictors of uveitis were age <7 years at JIA onset (Odds ratio (OR) 2.1, 95% confidence interval (CI) 1.3 to 3.5), presence of antihistone antibodies (AHA) > 15 U/ml (OR 4.8 (1.8 to 13.4)) and antinuclear antibodies (ANA) (OR 2.4 (1.5 to 4.0)). Mean combined IgM/IgG AHA was significantly higher in the uveitis group (19.2 U/ml) than in the non-uveitis group (10.2 U/ml) (p = 0.002). Young age at JIA onset predicted uveitis in girls (p <0.001), but not in boys (p = 0.390). Conclusion: Early-onset arthritis and presence of AHA in girls, as well as presence of ANA in both genders, were significant predictors of chronic uveitis. The high incidence of uveitis in this long-term Nordic JIA cohort may have severe implications in a lifelong perspective.
Subject: Juvenile idiopathic arthritis
Uveitis
Epidemiology
Biomarkers
Histones
Antinuclear antibody
FOLLOW-UP
ANTIHISTONE ANTIBODIES
ANTINUCLEAR ANTIBODIES
CLINICAL-FEATURES
NORTHERN NORWAY
DISEASE COURSE
RISK-FACTORS
PREVALENCE
COMPLICATIONS
CLASSIFICATION
3121 General medicine, internal medicine and other clinical medicine
3123 Gynaecology and paediatrics
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