1 Personality Polygenes, Positive Affect, and Life Satisfaction

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Weiss , A , Baselmans , B M L , Hofer , E , Yang , J , Okbay , A , Lind , P A , Miller , M B , Nolte , I M , Zhao , W , Hagenaars , S P , Hottenga , J-J , Matteson , L K , Snieder , H , Faul , J D , Hartman , C A , Boyle , P A , Tiemeier , H , Mosing , M A , Pattie , A , Davies , G , Liewald , D C , Schmidt , R , De Jager , P L , Heath , A C , Jokela , M , Starr , J M , Oldehinkel , A J , Johannesson , M , Cesarini , D , Hofman , A , Harris , S E , Smith , J A , Keltikangas-Järvinen , L , Pulkki-Råback , L , Schmidt , H , Smith , J , Iacono , W G , McGue , M , Bennett , D A , Pedersen , N L , Magnusson , P K E , Deary , I J , Martin , N G , Boomsma , D I , Bartels , M & Luciano , M 2016 , ' 1 Personality Polygenes, Positive Affect, and Life Satisfaction ' Twin Research and Human Genetics , vol. 19 , no. 5 , pp. 407-417 . DOI: 10.1017/thg.2016.65

Title: 1 Personality Polygenes, Positive Affect, and Life Satisfaction
Author: Weiss, Alexander; Baselmans, Bart M. L.; Hofer, Edith; Yang, Jingyun; Okbay, Aysu; Lind, Penelope A.; Miller, Mike B.; Nolte, Ilja M.; Zhao, Wei; Hagenaars, Saskia P.; Hottenga, Jouke-Jan; Matteson, Lindsay K.; Snieder, Harold; Faul, Jessica D.; Hartman, Catharina A.; Boyle, Patricia A.; Tiemeier, Henning; Mosing, Miriam A.; Pattie, Alison; Davies, Gail; Liewald, David C.; Schmidt, Reinhold; De Jager, Philip L.; Heath, Andrew C.; Jokela, Markus; Starr, John M.; Oldehinkel, Albertine J.; Johannesson, Magnus; Cesarini, David; Hofman, Albert; Harris, Sarah E.; Smith, Jennifer A.; Keltikangas-Järvinen, Liisa; Pulkki-Råback, Laura; Schmidt, Helena; Smith, Jacqui; Iacono, William G.; McGue, Matt; Bennett, David A.; Pedersen, Nancy L.; Magnusson, Patrik K. E.; Deary, Ian J.; Martin, Nicholas G.; Boomsma, Dorret I.; Bartels, Meike; Luciano, Michelle
Contributor: University of Helsinki, Behavioural Sciences
University of Helsinki, Behavioural Sciences
University of Helsinki, Helsinki Collegium for Advanced Studies
Date: 2016-10
Language: eng
Number of pages: 11
Belongs to series: Twin Research and Human Genetics
ISSN: 1832-4274
URI: http://hdl.handle.net/10138/224370
Abstract: Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes
Subject: wellbeing
genetics
polygenic prediction
happiness
genetic correlation
GENOME-WIDE ASSOCIATION
TRAITS
METAANALYSIS
NEUROTICISM
GENETICS
TWIN
HERITABILITY
HAPPINESS
VARIANTS
DISORDER
1184 Genetics, developmental biology, physiology
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